IL23A_HORSE
ID IL23A_HORSE Reviewed; 192 AA.
AC Q64FU1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Interleukin-23 subunit alpha;
DE Short=IL-23 subunit alpha;
DE Short=IL-23-A;
DE AltName: Full=Interleukin-23 subunit p19;
DE Short=IL-23p19;
DE Flags: Precursor;
GN Name=IL23A;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16293125; DOI=10.1111/j.1365-2052.2005.01348.x;
RA Musilova P., Kubickova S., Vychodilova-Krenkova L., Kralik P.,
RA Matiasovic J., Hubertova D., Rubes J., Horin P.;
RT "Cytogenetic mapping of immunity-related genes in the domestic horse.";
RL Anim. Genet. 36:507-510(2005).
CC -!- FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine
CC IL-23 that plays different roles in innate and adaptive immunity.
CC Released by antigen-presenting cells such as dendritic cells or
CC macrophages, binds to a heterodimeric receptor complex composed of
CC IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate
CC the receptor to form a docking site leading to the phosphorylation of
CC STAT3 and STAT4. This process leads to activation of several pathways
CC including p38 MAPK or NF-kappa-B and promotes the production of pro-
CC inflammatory cytokines such as interleukin-17A/IL17A. In turn,
CC participates in the early and effective intracellular bacterial
CC clearance. Promotes the expansion and survival of T-helper 17 cells, a
CC CD4-positive helper T-cell subset that produces IL-17, as well as other
CC IL-17-producing cells. {ECO:0000250|UniProtKB:Q9NPF7}.
CC -!- SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is
CC known as interleukin IL-23. Interacts with IL23R; this interaction
CC enables recruitment of IL12RB1. {ECO:0000250|UniProtKB:Q9NPF7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted upon
CC association with IL12B. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR EMBL; AY704416; AAU13947.1; -; Genomic_DNA.
DR RefSeq; NP_001075991.1; NM_001082522.2.
DR AlphaFoldDB; Q64FU1; -.
DR SMR; Q64FU1; -.
DR STRING; 9796.ENSECAP00000019716; -.
DR PaxDb; Q64FU1; -.
DR Ensembl; ENSECAT00000023772; ENSECAP00000019716; ENSECAG00000022310.
DR GeneID; 100034230; -.
DR KEGG; ecb:100034230; -.
DR CTD; 51561; -.
DR VGNC; VGNC:19021; IL23A.
DR GeneTree; ENSGT00390000006482; -.
DR HOGENOM; CLU_122915_0_0_1; -.
DR InParanoid; Q64FU1; -.
DR OMA; WARCQQL; -.
DR OrthoDB; 1709263at2759; -.
DR TreeFam; TF337234; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000022310; Expressed in gluteus medius and 20 other tissues.
DR ExpressionAtlas; Q64FU1; baseline.
DR GO; GO:0070743; C:interleukin-23 complex; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0043382; P:positive regulation of memory T cell differentiation; IEA:Ensembl.
DR GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IEA:Ensembl.
DR GO; GO:2000330; P:positive regulation of T-helper 17 cell lineage commitment; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR GO; GO:0048771; P:tissue remodeling; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR010831; IL-23_alpha.
DR PANTHER; PTHR15947; PTHR15947; 1.
DR Pfam; PF16649; IL23; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 3: Inferred from homology;
KW Antiviral defense; Cytokine; Disulfide bond; Immunity;
KW Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW Signal; Tissue remodeling.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..192
FT /note="Interleukin-23 subunit alpha"
FT /id="PRO_0000259487"
SQ SEQUENCE 192 AA; 21042 MW; 9898C79BC9E22E4F CRC64;
MLGSRAVLLL LLLLWPRTAQ ARAVPGGSSP AWAQCQQLSQ KLCTLAWSAH PPMGHVDLPR
EEGDAETTND VPHIQCEDGC DPEGLRDNSQ PCLQRIHQGL VFYEKLLGSD IFTGEPSLLP
NGPVDQLHAS LLGLRQLLQP EGHHWETEQI PSPSPSQPWQ RLLLRPKILR SLQAFVAVAA
RVFAHGAATL TP
