ID   IL23A_PIG               Reviewed;         193 AA.
AC   Q9N2H9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Interleukin-23 subunit alpha;
DE            Short=IL-23 subunit alpha;
DE            Short=IL-23-A;
DE   AltName: Full=Interleukin-23 subunit p19;
DE            Short=IL-23p19;
DE   Flags: Precursor;
GN   Name=IL23A; Synonyms=SGRF;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Hirata Y., Kosuge Y.;
RT   "SGRF; a novel member of the IL-6/G-CSF family.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine
CC       IL-23 that plays different roles in innate and adaptive immunity.
CC       Released by antigen-presenting cells such as dendritic cells or
CC       macrophages, binds to a heterodimeric receptor complex composed of
CC       IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate
CC       the receptor to form a docking site leading to the phosphorylation of
CC       STAT3 and STAT4. This process leads to activation of several pathways
CC       including p38 MAPK or NF-kappa-B and promotes the production of pro-
CC       inflammatory cytokines such as interleukin-17A/IL17A. In turn,
CC       participates in the early and effective intracellular bacterial
CC       clearance. Promotes the expansion and survival of T-helper 17 cells, a
CC       CD4-positive helper T-cell subset that produces IL-17, as well as other
CC       IL-17-producing cells. {ECO:0000250|UniProtKB:Q9NPF7}.
CC   -!- SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is
CC       known as interleukin IL-23. Interacts with IL23R; this interaction
CC       enables recruitment of IL12RB1. {ECO:0000250|UniProtKB:Q9NPF7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted upon
CC       association with IL12B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB030002; BAA93688.1; -; Genomic_DNA.
DR   RefSeq; NP_001123708.1; NM_001130236.1.
DR   AlphaFoldDB; Q9N2H9; -.
DR   SMR; Q9N2H9; -.
DR   PRIDE; Q9N2H9; -.
DR   Ensembl; ENSSSCT00000047550; ENSSSCP00000039363; ENSSSCG00000033520.
DR   Ensembl; ENSSSCT00005036711; ENSSSCP00005022424; ENSSSCG00005023163.
DR   Ensembl; ENSSSCT00015102848; ENSSSCP00015042770; ENSSSCG00015076163.
DR   Ensembl; ENSSSCT00025045106; ENSSSCP00025019215; ENSSSCG00025033168.
DR   Ensembl; ENSSSCT00030042027; ENSSSCP00030019113; ENSSSCG00030030253.
DR   Ensembl; ENSSSCT00035012004; ENSSSCP00035004090; ENSSSCG00035009567.
DR   Ensembl; ENSSSCT00040006505; ENSSSCP00040002598; ENSSSCG00040004892.
DR   Ensembl; ENSSSCT00045039391; ENSSSCP00045027405; ENSSSCG00045023071.
DR   Ensembl; ENSSSCT00050093136; ENSSSCP00050040184; ENSSSCG00050068256.
DR   Ensembl; ENSSSCT00055022222; ENSSSCP00055017610; ENSSSCG00055011309.
DR   Ensembl; ENSSSCT00060108143; ENSSSCP00060048133; ENSSSCG00060078317.
DR   Ensembl; ENSSSCT00065088154; ENSSSCP00065038572; ENSSSCG00065064201.
DR   Ensembl; ENSSSCT00070059332; ENSSSCP00070050521; ENSSSCG00070029520.
DR   GeneID; 100155546; -.
DR   KEGG; ssc:100155546; -.
DR   CTD; 51561; -.
DR   VGNC; VGNC:89099; IL23A.
DR   GeneTree; ENSGT00390000006482; -.
DR   InParanoid; Q9N2H9; -.
DR   OMA; WARCQQL; -.
DR   OrthoDB; 1344829at2759; -.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Proteomes; UP000314985; Chromosome 5.
DR   Bgee; ENSSSCG00000033520; Expressed in granulosa cell and 11 other tissues.
DR   GO; GO:0070743; C:interleukin-23 complex; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IBA:GO_Central.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0043382; P:positive regulation of memory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IEA:Ensembl.
DR   GO; GO:2000330; P:positive regulation of T-helper 17 cell lineage commitment; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR   GO; GO:0048771; P:tissue remodeling; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010831; IL-23_alpha.
DR   PANTHER; PTHR15947; PTHR15947; 1.
DR   Pfam; PF16649; IL23; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Cytokine; Disulfide bond; Immunity;
KW   Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW   Signal; Tissue remodeling.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..193
FT                   /note="Interleukin-23 subunit alpha"
FT                   /id="PRO_0000259490"
SQ   SEQUENCE   193 AA;  21132 MW;  05F28DE94810B9E1 CRC64;
     MLGSRAVMLM LLLLLLPWTS QGRAVPEGSS PAWAQGQQLS QQLCTLAWTA HLPMGHVDLP
     REEGDDETTS EVPHIQCGDG CDPQGLRDNS QSCLQRIHQG LVFYEKLLGS DIFTGEPSLH
     PDGSVGQLHA SLLGLRQLLQ PEGHHWETEQ TPSPSPSQPW QRLLLRLKIL RSLQAFVAVA
     ARVFAHGAAT LSQ