IL23A_RAT
ID IL23A_RAT Reviewed; 196 AA.
AC Q91Z84;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Interleukin-23 subunit alpha;
DE Short=IL-23 subunit alpha;
DE Short=IL-23-A;
DE AltName: Full=Interleukin-23 subunit p19;
DE Short=IL-23p19;
DE Flags: Precursor;
GN Name=Il23a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Lewis;
RA Tran G., Hodgkinson S.;
RT "Rattus norvegicus IL-23 mRNA.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Brown Norway; TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine
CC IL-23 that plays different roles in innate and adaptive immunity.
CC Released by antigen-presenting cells such as dendritic cells or
CC macrophages, binds to a heterodimeric receptor complex composed of
CC IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate
CC the receptor to form a docking site leading to the phosphorylation of
CC STAT3 and STAT4. This process leads to activation of several pathways
CC including p38 MAPK or NF-kappa-B and promotes the production of pro-
CC inflammatory cytokines such as interleukin-17A/IL17A. In turn,
CC participates in the early and effective intracellular bacterial
CC clearance. Promotes the expansion and survival of T-helper 17 cells, a
CC CD4-positive helper T-cell subset that produces IL-17, as well as other
CC IL-17-producing cells. {ECO:0000250|UniProtKB:Q9NPF7}.
CC -!- SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is
CC known as interleukin IL-23. Interacts with IL23R; this interaction
CC enables recruitment of IL12RB1. {ECO:0000250|UniProtKB:Q9NPF7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted upon
CC association with IL12B. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR EMBL; AY055379; AAL18229.1; -; mRNA.
DR EMBL; BC098907; AAH98907.1; -; mRNA.
DR RefSeq; NP_569094.1; NM_130410.2.
DR AlphaFoldDB; Q91Z84; -.
DR SMR; Q91Z84; -.
DR STRING; 10116.ENSRNOP00000004363; -.
DR PaxDb; Q91Z84; -.
DR PRIDE; Q91Z84; -.
DR Ensembl; ENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
DR GeneID; 155140; -.
DR KEGG; rno:155140; -.
DR UCSC; RGD:620873; rat.
DR CTD; 51561; -.
DR RGD; 620873; Il23a.
DR eggNOG; ENOG502STAQ; Eukaryota.
DR GeneTree; ENSGT00390000006482; -.
DR HOGENOM; CLU_122915_0_0_1; -.
DR InParanoid; Q91Z84; -.
DR OMA; WARCQQL; -.
DR OrthoDB; 1344829at2759; -.
DR PhylomeDB; Q91Z84; -.
DR TreeFam; TF337234; -.
DR Reactome; R-RNO-9020933; Interleukin-23 signaling.
DR PRO; PR:Q91Z84; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000003254; Expressed in thymus and 18 other tissues.
DR Genevisible; Q91Z84; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0070743; C:interleukin-23 complex; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISO:RGD.
DR GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISO:RGD.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; ISO:RGD.
DR GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:RGD.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:RGD.
DR GO; GO:0043382; P:positive regulation of memory T cell differentiation; ISO:RGD.
DR GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:RGD.
DR GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; ISO:RGD.
DR GO; GO:0051135; P:positive regulation of NK T cell activation; ISO:RGD.
DR GO; GO:0051142; P:positive regulation of NK T cell proliferation; ISO:RGD.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISO:RGD.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:RGD.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; ISO:RGD.
DR GO; GO:2000330; P:positive regulation of T-helper 17 cell lineage commitment; ISO:RGD.
DR GO; GO:2000318; P:positive regulation of T-helper 17 type immune response; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0042098; P:T cell proliferation; ISO:RGD.
DR GO; GO:0048771; P:tissue remodeling; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR010831; IL-23_alpha.
DR PANTHER; PTHR15947; PTHR15947; 1.
DR Pfam; PF16649; IL23; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Antiviral defense; Cytokine; Disulfide bond; Immunity;
KW Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW Signal; Tissue remodeling.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..196
FT /note="Interleukin-23 subunit alpha"
FT /id="PRO_0000259491"
SQ SEQUENCE 196 AA; 21986 MW; 188FF74BC409A961 CRC64;
MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP VGQMDLLREE
GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF YKHLLDSDIF TGEPSLLPDS
PVDQLHTSLL GLSQLLQPED HHWETQQMPR LSPSQQWQRS LLRSKILRSL QAFLAIAARV
FAHGAATLTE PLVPTA
