APMAP_HUMAN
ID APMAP_HUMAN Reviewed; 416 AA.
AC Q9HDC9; A8K514; B4DXG1; Q6UVZ8; Q9GZS8; Q9NUB2;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Adipocyte plasma membrane-associated protein;
DE AltName: Full=Protein BSCv;
GN Name=APMAP; Synonyms=C20orf3; ORFNames=UNQ1869/PRO4305;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10945474; DOI=10.1006/geno.2000.6237;
RA Morita M., Hara Y., Tamai Y., Arakawa H., Nishimura S.;
RT "Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin
RT F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).";
RL Genomics 67:87-91(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adipose tissue, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-416 (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [6]
RP GLYCOSYLATION AT ASN-160 AND ASN-196.
RX PubMed=12754519; DOI=10.1038/nbt827;
RA Zhang H., Li X.-J., Martin D.B., Aebersold R.;
RT "Identification and quantification of N-linked glycoproteins using
RT hydrazide chemistry, stable isotope labeling and mass spectrometry.";
RL Nat. Biotechnol. 21:660-666(2003).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-196.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND VARIANTS GLN-282
RP AND TRP-374.
RX PubMed=18513186; DOI=10.1042/bj20080503;
RA Ilhan A., Gartner W., Nabokikh A., Daneva T., Majdic O., Cohen G.,
RA Boehmig G.A., Base W., Hoerl W.H., Wagner L.;
RT "Localization and characterization of the novel protein encoded by
RT C20orf3.";
RL Biochem. J. 414:485-495(2008).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-196.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Exhibits strong arylesterase activity with beta-naphthyl
CC acetate and phenyl acetate. May play a role in adipocyte
CC differentiation. {ECO:0000269|PubMed:18513186}.
CC -!- INTERACTION:
CC Q9HDC9; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-723950, EBI-18304435;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:18513186}; Single-
CC pass type II membrane protein {ECO:0000269|PubMed:18513186}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9HDC9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HDC9-2; Sequence=VSP_036992, VSP_036993;
CC -!- TISSUE SPECIFICITY: Liver, glomerular and tubular structures of the
CC kidney, endothelial cells, arterial wall and pancreatic islets of
CC Langerhans (at protein level). Found ubiquitously in adult as well as
CC in embryonic tissues. In adult tissue, the highest expression is found
CC in the liver, placenta and heart. Found on the cell surface of
CC monocytes. In embryonic tissue, the highest expression levels is found
CC in the liver and the kidney. {ECO:0000269|PubMed:18513186}.
CC -!- SIMILARITY: Belongs to the strictosidine synthase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89435.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB11885.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15253.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB15578.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB033767; BAB11885.1; ALT_INIT; mRNA.
DR EMBL; AK291129; BAF83818.1; -; mRNA.
DR EMBL; AK301959; BAG63373.1; -; mRNA.
DR EMBL; AL035661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003501; AAH03501.1; -; mRNA.
DR EMBL; AY359076; AAQ89435.1; ALT_INIT; mRNA.
DR EMBL; AK025834; BAB15253.1; ALT_INIT; mRNA.
DR EMBL; AK026866; BAB15578.1; ALT_INIT; mRNA.
DR CCDS; CCDS13166.1; -. [Q9HDC9-1]
DR RefSeq; NP_065392.1; NM_020531.2. [Q9HDC9-1]
DR RefSeq; XP_005260820.1; XM_005260763.3. [Q9HDC9-2]
DR AlphaFoldDB; Q9HDC9; -.
DR SMR; Q9HDC9; -.
DR BioGRID; 121397; 47.
DR IntAct; Q9HDC9; 35.
DR MINT; Q9HDC9; -.
DR STRING; 9606.ENSP00000217456; -.
DR GlyConnect; 797; 38 N-Linked glycans (2 sites).
DR GlyGen; Q9HDC9; 3 sites, 44 N-linked glycans (2 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q9HDC9; -.
DR MetOSite; Q9HDC9; -.
DR PhosphoSitePlus; Q9HDC9; -.
DR SwissPalm; Q9HDC9; -.
DR BioMuta; APMAP; -.
DR DMDM; 24211474; -.
DR CPTAC; CPTAC-1280; -.
DR CPTAC; CPTAC-648; -.
DR EPD; Q9HDC9; -.
DR jPOST; Q9HDC9; -.
DR MassIVE; Q9HDC9; -.
DR MaxQB; Q9HDC9; -.
DR PaxDb; Q9HDC9; -.
DR PeptideAtlas; Q9HDC9; -.
DR PRIDE; Q9HDC9; -.
DR ProteomicsDB; 81851; -. [Q9HDC9-1]
DR ProteomicsDB; 81852; -. [Q9HDC9-2]
DR Antibodypedia; 2012; 300 antibodies from 22 providers.
DR DNASU; 57136; -.
DR Ensembl; ENST00000217456.3; ENSP00000217456.2; ENSG00000101474.12. [Q9HDC9-1]
DR GeneID; 57136; -.
DR KEGG; hsa:57136; -.
DR MANE-Select; ENST00000217456.3; ENSP00000217456.2; NM_020531.3; NP_065392.1.
DR UCSC; uc002wty.4; human. [Q9HDC9-1]
DR CTD; 57136; -.
DR DisGeNET; 57136; -.
DR GeneCards; APMAP; -.
DR HGNC; HGNC:13238; APMAP.
DR HPA; ENSG00000101474; Tissue enhanced (liver).
DR MIM; 615884; gene.
DR neXtProt; NX_Q9HDC9; -.
DR OpenTargets; ENSG00000101474; -.
DR PharmGKB; PA25745; -.
DR VEuPathDB; HostDB:ENSG00000101474; -.
DR eggNOG; KOG1520; Eukaryota.
DR GeneTree; ENSGT00440000039984; -.
DR HOGENOM; CLU_023267_0_0_1; -.
DR InParanoid; Q9HDC9; -.
DR OMA; ERLWENQ; -.
DR OrthoDB; 757814at2759; -.
DR PhylomeDB; Q9HDC9; -.
DR TreeFam; TF316475; -.
DR PathwayCommons; Q9HDC9; -.
DR SignaLink; Q9HDC9; -.
DR BioGRID-ORCS; 57136; 8 hits in 1077 CRISPR screens.
DR ChiTaRS; APMAP; human.
DR GeneWiki; C20orf3; -.
DR GenomeRNAi; 57136; -.
DR Pharos; Q9HDC9; Tbio.
DR PRO; PR:Q9HDC9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9HDC9; protein.
DR Bgee; ENSG00000101474; Expressed in cerebellar vermis and 201 other tissues.
DR ExpressionAtlas; Q9HDC9; baseline and differential.
DR Genevisible; Q9HDC9; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0004064; F:arylesterase activity; IDA:UniProtKB.
DR GO; GO:0016844; F:strictosidine synthase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 2.120.10.30; -; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR018119; Strictosidine_synth_cons-reg.
DR Pfam; PF03088; Str_synth; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..416
FT /note="Adipocyte plasma membrane-associated protein"
FT /id="PRO_0000205945"
FT TOPO_DOM 2..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..416
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 19
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754519,
FT ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218"
FT VAR_SEQ 283..289
FT /note="RVYVSGL -> SSLVKRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036992"
FT VAR_SEQ 290..416
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036993"
FT VARIANT 65
FT /note="I -> V (in dbSNP:rs12242)"
FT /id="VAR_014128"
FT VARIANT 282
FT /note="R -> Q (in dbSNP:rs35097515)"
FT /evidence="ECO:0000269|PubMed:18513186"
FT /id="VAR_055039"
FT VARIANT 374
FT /note="R -> W (in dbSNP:rs28364786)"
FT /evidence="ECO:0000269|PubMed:18513186"
FT /id="VAR_055040"
FT CONFLICT 12
FT /note="P -> A (in Ref. 2; BAG63373)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="E -> G (in Ref. 2; BAF83818)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="D -> G (in Ref. 2; BAF83818)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="V -> A (in Ref. 2; BAF83818)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 416 AA; 46480 MW; C88E2DF2DF6093C4 CRC64;
MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL TVPLLGAMML
LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV GPESIAHIGD VMFTGTADGR
VVKLENGEIE TIARFGSGPC KTRDDEPVCG RPLGIRAGPN GTLFVADAYK GLFEVNPWKR
EVKLLLSSET PIEGKNMSFV NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL
EYDTVTREVK VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN
MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS QETVMKFVPR
YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL GSFRSPFLCR LSLQAV
