IL23R_MOUSE
ID IL23R_MOUSE Reviewed; 644 AA.
AC Q8K4B4;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Interleukin-23 receptor;
DE Short=IL-23 receptor;
DE Short=IL-23R;
DE Flags: Precursor;
GN Name=Il23r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=T-cell;
RX PubMed=12023369; DOI=10.4049/jimmunol.168.11.5699;
RA Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J.,
RA Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J.,
RA O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D.,
RA Rennick D.M., Kastelein R.A., de Waal Malefyt R., Moore K.W.;
RT "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1
RT and a novel cytokine receptor subunit, IL-23R.";
RL J. Immunol. 168:5699-5708(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor.
CC Binds IL23 and mediates T-cells, NK cells and possibly certain
CC macrophage/myeloid cells stimulation probably through activation of the
CC Jak-Stat signaling cascade. IL23 functions in innate and adaptive
CC immunity and may participate in acute response to infection in
CC peripheral tissues. IL23 may be responsible for autoimmune inflammatory
CC diseases and be important for tumorigenesis (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with IL12RB1. In presence of IL23, the heterodimer
CC forms the IL23 receptor. Interacts with JAK2 and in presence of IL23
CC with STAT3 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by Th1, Th2 and dendritic cells.
CC {ECO:0000269|PubMed:12023369}.
CC -!- PTM: Phosphorylated in response to IL23. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF461423; AAM44230.1; -; mRNA.
DR EMBL; BC112425; AAI12426.1; -; mRNA.
DR CCDS; CCDS39503.2; -.
DR RefSeq; NP_653131.2; NM_144548.1.
DR AlphaFoldDB; Q8K4B4; -.
DR SMR; Q8K4B4; -.
DR ComplexPortal; CPX-389; Interleukin-23-receptor complex.
DR STRING; 10090.ENSMUSP00000113342; -.
DR ChEMBL; CHEMBL4523394; -.
DR GlyGen; Q8K4B4; 3 sites.
DR iPTMnet; Q8K4B4; -.
DR PhosphoSitePlus; Q8K4B4; -.
DR PaxDb; Q8K4B4; -.
DR PRIDE; Q8K4B4; -.
DR DNASU; 209590; -.
DR Ensembl; ENSMUST00000118364; ENSMUSP00000113342; ENSMUSG00000049093.
DR GeneID; 209590; -.
DR KEGG; mmu:209590; -.
DR CTD; 149233; -.
DR MGI; MGI:2181693; Il23r.
DR eggNOG; ENOG502QUIH; Eukaryota.
DR GeneTree; ENSGT00530000064198; -.
DR InParanoid; Q8K4B4; -.
DR OrthoDB; 144839at2759; -.
DR PhylomeDB; Q8K4B4; -.
DR Reactome; R-MMU-9020933; Interleukin-23 signaling.
DR BioGRID-ORCS; 209590; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8K4B4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K4B4; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0072536; C:interleukin-23 receptor complex; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0005143; F:interleukin-12 receptor binding; ISO:MGI.
DR GO; GO:0042019; F:interleukin-23 binding; ISO:MGI.
DR GO; GO:0042020; F:interleukin-23 receptor activity; ISO:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0006955; P:immune response; IC:ComplexPortal.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0002443; P:leukocyte mediated immunity; ISO:MGI.
DR GO; GO:0032693; P:negative regulation of interleukin-10 production; ISO:MGI.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; ISO:MGI.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:MGI.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IC:ComplexPortal.
DR GO; GO:0051142; P:positive regulation of NK T cell proliferation; IC:ComplexPortal.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:ComplexPortal.
DR GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; ISO:MGI.
DR GO; GO:2000318; P:positive regulation of T-helper 17 type immune response; IC:ComplexPortal.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:MGI.
DR GO; GO:0034341; P:response to interferon-gamma; ISO:MGI.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Immunity; Inflammatory response;
KW Innate immunity; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..644
FT /note="Interleukin-23 receptor"
FT /id="PRO_0000268663"
FT TOPO_DOM 24..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..644
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 127..217
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 219..318
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 644 AA; 73453 MW; AA461FD270E599D2 CRC64;
MSHLTLQLHV VIALYVLFRW CHGGITSINC SGDMWVEPGE IFQMGMNVSI YCQEALKHCR
PRNLYFYKNG FKEEFDITRI NRTTARIWYK GFSEPHAYMH CTAECPGHFQ ETLICGKDIS
SGHPPDAPSN LTCVIYEYSG NMTCTWNTGK PTYIDTKYIV HVKSLETEEE QQYLASSYVK
ISTDSLQGSR KYLVWVQAVN SLGMENSQQL HVHLDDIVIP SASIISRAET TNDTVPKTIV
YWKSKTMIEK VFCEMRYKTT TNQTWSVKEF DANFTYVQQS EFYLEPDSKY VFQVRCQETG
KRNWQPWSSP FVHQTSQETG KRNWQPWSSP FVHQTSQTVS QVTAKSSHEP QKMEMLSATI
FRGHPASGNH QDIGLLSGMV FLAIMLPIFS LIGIFNRSLR IGIKRKVLLM IPKWLYEDIP
NMENSNVAKL LQEKSVFEND NASEQALYVD PVLTEISEIS PLEHKPTDYK EERLTGLLET
RDCPLGMLST SSSVVYIPDL NTGYKPQVSN VPPGGNLFIN RDERDPTSLE TTDDHFARLK
TYPNFQFSAS SMALLNKTLI LDELCLVLNQ GEFNSLDIKN SRQEETSIVL QSDSPSETIP
AQTLLSDEFV SCLAIGNEDL PSINSYFPQN VLESHFSRIS LFQK
