IL24_MOUSE
ID IL24_MOUSE Reviewed; 181 AA.
AC Q925S4; Q925J3;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Interleukin-24;
DE Short=IL-24;
DE AltName: Full=IL-4-induced secreted protein;
DE AltName: Full=Melanoma differentiation-associated gene 7 protein;
DE Short=MDA-7;
DE AltName: Full=Th2-specific cytokine FISP;
DE Flags: Precursor;
GN Name=Il24; Synonyms=Mda7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/SvJ;
RA Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.;
RT "Genomic structure, chromosomal localization and expression of melanoma
RT differentiation associated gene-7 (mda-7): potential relationship with
RT cellular senescence.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=BALB/cJ;
RX PubMed=11342597; DOI=10.4049/jimmunol.166.10.5859;
RA Schaefer G., Venkataraman C., Schindler U.;
RT "FISP (IL-4-induced secreted protein), a novel cytokine-like molecule
RT secreted by Th2 cells.";
RL J. Immunol. 166:5859-5863(2001).
CC -!- FUNCTION: Has antiproliferative properties on melanoma cells and may
CC contribute to terminal cell differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Selectively expressed by Th2 cells.
CC {ECO:0000269|PubMed:11342597}.
CC -!- INDUCTION: By IL-4. {ECO:0000269|PubMed:11342597}.
CC -!- PTM: Ubiquitination at Lys-97 promotes proteasomal degradation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK52470.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF235006; AAK52590.1; -; mRNA.
DR EMBL; AF333251; AAK52470.1; ALT_INIT; mRNA.
DR CCDS; CCDS15262.2; -.
DR RefSeq; NP_444325.2; NM_053095.2.
DR AlphaFoldDB; Q925S4; -.
DR SMR; Q925S4; -.
DR STRING; 10090.ENSMUSP00000113064; -.
DR GlyGen; Q925S4; 1 site.
DR iPTMnet; Q925S4; -.
DR PhosphoSitePlus; Q925S4; -.
DR PaxDb; Q925S4; -.
DR PRIDE; Q925S4; -.
DR DNASU; 93672; -.
DR GeneID; 93672; -.
DR KEGG; mmu:93672; -.
DR CTD; 11009; -.
DR MGI; MGI:2135548; Il24.
DR eggNOG; ENOG502SUXZ; Eukaryota.
DR InParanoid; Q925S4; -.
DR OrthoDB; 1434107at2759; -.
DR PhylomeDB; Q925S4; -.
DR TreeFam; TF333253; -.
DR BioGRID-ORCS; 93672; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q925S4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q925S4; protein.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; ISA:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
DR GO; GO:0042501; P:serine phosphorylation of STAT protein; ISO:MGI.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020444; IL-24.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01937; INTRLEUKIN24.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytokine; Glycoprotein; Isopeptide bond; Reference proteome;
KW Secreted; Signal; Ubl conjugation.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..181
FT /note="Interleukin-24"
FT /id="PRO_0000042240"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CROSSLNK 97
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:Q13007"
FT CONFLICT 31
FT /note="S -> F (in Ref. 2; AAK52470)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 181 AA; 20812 MW; 05CA43872D53D555 CRC64;
MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD
ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI
VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH
L
