ID   IL26_HUMAN              Reviewed;         171 AA.
AC   Q9NPH9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Interleukin-26;
DE            Short=IL-26;
DE   AltName: Full=Protein AK155;
DE   Flags: Precursor;
GN   Name=IL26; Synonyms=AK155;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=10729163; DOI=10.1128/jvi.74.8.3881-3887.2000;
RA   Knappe A., Hor S., Wittmann S., Fickenscher H.;
RT   "Induction of a novel cellular homolog of interleukin-10, AK155, by
RT   transformation of T lymphocytes with herpesvirus saimiri.";
RL   J. Virol. 74:3881-3887(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   SeattleSNPs variation discovery resource;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=15178681; DOI=10.1074/jbc.m405000200;
RA   Hor S., Pirzer H., Dumoutier L., Bauer F., Wittmann S., Sticht H.,
RA   Renauld J.C., de Waal Malefyt R., Fickenscher H.;
RT   "The T-cell lymphokine interleukin-26 targets epithelial cells through the
RT   interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.";
RL   J. Biol. Chem. 279:33343-33351(2004).
RN   [5]
RP   FUNCTION, AND RECEPTOR-BINDING.
RX   PubMed=14764663; DOI=10.4049/jimmunol.172.4.2006;
RA   Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V.,
RA   Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A.,
RA   Donnelly R.P., Kotenko S.V.;
RT   "IL-26 signals through a novel receptor complex composed of IL-20 receptor
RT   1 and IL-10 receptor 2.";
RL   J. Immunol. 172:2006-2010(2004).
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=18483078; DOI=10.1136/gut.2007.130112;
RA   Dambacher J., Beigel F., Zitzmann K., De Toni E.N., Goke B.,
RA   Diepolder H.M., Auernhammer C.J., Brand S.;
RT   "The role of the novel Th17 cytokine IL-26 in intestinal inflammation.";
RL   Gut 58:1207-1217(2009).
CC   -!- FUNCTION: May play a role in local mechanisms of mucosal immunity and
CC       seems to have a pro-inflammatory function. May play a role in
CC       inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3
CC       (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8,
CC       secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases
CC       proliferation of intestinal epithelial cells. Is inhibited by heparin.
CC       {ECO:0000269|PubMed:14764663, ECO:0000269|PubMed:15178681,
CC       ECO:0000269|PubMed:18483078}.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18483078}.
CC   -!- TISSUE SPECIFICITY: Expressed in HVS transformed T-cells but not other
CC       T-cell lines or primary stimulated T-cells. Expressed in colonic T-
CC       cells including Th17 inflammatory T-cells; the expression is
CC       significantly increased in serum of patients with Crohn's disease (at
CC       protein level). {ECO:0000269|PubMed:18483078}.
CC   -!- INDUCTION: By Herpesvirus saimiri infection.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-26 entry;
CC       URL="https://en.wikipedia.org/wiki/Interleukin_26";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il26/";
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DR   EMBL; AJ251550; CAB77049.1; -; Genomic_DNA.
DR   EMBL; AJ251551; CAB77049.1; JOINED; Genomic_DNA.
DR   EMBL; AJ251549; CAB76942.1; -; mRNA.
DR   EMBL; AY509906; AAR87776.1; -; Genomic_DNA.
DR   EMBL; BC066270; AAH66270.1; -; mRNA.
DR   EMBL; BC066271; AAH66271.1; -; mRNA.
DR   CCDS; CCDS8981.1; -.
DR   RefSeq; NP_060872.1; NM_018402.1.
DR   AlphaFoldDB; Q9NPH9; -.
DR   SMR; Q9NPH9; -.
DR   BioGRID; 120913; 15.
DR   STRING; 9606.ENSP00000229134; -.
DR   iPTMnet; Q9NPH9; -.
DR   PhosphoSitePlus; Q9NPH9; -.
DR   BioMuta; IL26; -.
DR   DMDM; 17366984; -.
DR   MassIVE; Q9NPH9; -.
DR   PaxDb; Q9NPH9; -.
DR   PeptideAtlas; Q9NPH9; -.
DR   PRIDE; Q9NPH9; -.
DR   ProteomicsDB; 82013; -.
DR   Antibodypedia; 29298; 243 antibodies from 25 providers.
DR   DNASU; 55801; -.
DR   Ensembl; ENST00000229134.5; ENSP00000229134.4; ENSG00000111536.5.
DR   GeneID; 55801; -.
DR   KEGG; hsa:55801; -.
DR   MANE-Select; ENST00000229134.5; ENSP00000229134.4; NM_018402.2; NP_060872.1.
DR   UCSC; uc001stx.2; human.
DR   CTD; 55801; -.
DR   DisGeNET; 55801; -.
DR   GeneCards; IL26; -.
DR   HGNC; HGNC:17119; IL26.
DR   HPA; ENSG00000111536; Tissue enhanced (lymphoid).
DR   MIM; 605679; gene.
DR   neXtProt; NX_Q9NPH9; -.
DR   OpenTargets; ENSG00000111536; -.
DR   PharmGKB; PA29826; -.
DR   VEuPathDB; HostDB:ENSG00000111536; -.
DR   eggNOG; ENOG502S3YD; Eukaryota.
DR   GeneTree; ENSGT00950000183124; -.
DR   HOGENOM; CLU_1598376_0_0_1; -.
DR   InParanoid; Q9NPH9; -.
DR   OMA; CKEIHFV; -.
DR   OrthoDB; 1403426at2759; -.
DR   PhylomeDB; Q9NPH9; -.
DR   TreeFam; TF333253; -.
DR   PathwayCommons; Q9NPH9; -.
DR   Reactome; R-HSA-8854691; Interleukin-20 family signaling.
DR   SignaLink; Q9NPH9; -.
DR   SIGNOR; Q9NPH9; -.
DR   BioGRID-ORCS; 55801; 9 hits in 1060 CRISPR screens.
DR   GeneWiki; Interleukin_26; -.
DR   GenomeRNAi; 55801; -.
DR   Pharos; Q9NPH9; Tbio.
DR   PRO; PR:Q9NPH9; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NPH9; protein.
DR   Bgee; ENSG00000111536; Expressed in vermiform appendix and 38 other tissues.
DR   Genevisible; Q9NPH9; HS.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IDA:UniProtKB.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IDA:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IDA:UniProtKB.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB.
DR   GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:UniProtKB.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   Pfam; PF00726; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..171
FT                   /note="Interleukin-26"
FT                   /id="PRO_0000015387"
SQ   SEQUENCE   171 AA;  19843 MW;  31F6261E42B6ACC0 CRC64;
     MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA WLKATIPEDR
     IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ GCKKIRFVED FHSLRQKLSH
     CISCASSARE MKSITRMKRI FYRIGNKGIY KAISELDILL SWIKKLLESS Q