IL2RA_FELCA
ID IL2RA_FELCA Reviewed; 275 AA.
AC P41690;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Interleukin-2 receptor subunit alpha;
DE Short=IL-2 receptor subunit alpha;
DE Short=IL-2-RA;
DE Short=IL-2R subunit alpha;
DE Short=IL2-RA;
DE AltName: CD_antigen=CD25;
DE Flags: Precursor;
GN Name=IL2RA;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Matsumoto Y., Ohno K., Goitsuka R., Hirota Y., Tsujimoto H., Hasegawa A.;
RT "Molecular cloning of the feline interleukin 2 receptor alpha chain cDNA.";
RL Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for interleukin-2. The receptor is involved in the
CC regulation of immune tolerance by controlling regulatory T cells
CC (TREGs) activity. TREGs suppress the activation and expansion of
CC autoreactive T-cells. {ECO:0000250|UniProtKB:P01589}.
CC -!- SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists
CC in 3 different forms: a high affinity dimer, an intermediate affinity
CC monomer (beta subunit), and a low affinity monomer (alpha subunit). The
CC high and intermediate affinity forms also associate with a gamma
CC subunit (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; D16143; BAA03714.1; -; mRNA.
DR RefSeq; NP_001009355.1; NM_001009355.1.
DR AlphaFoldDB; P41690; -.
DR SMR; P41690; -.
DR STRING; 9685.ENSFCAP00000005380; -.
DR PRIDE; P41690; -.
DR Ensembl; ENSFCAT00000005796; ENSFCAP00000005380; ENSFCAG00000005794.
DR GeneID; 493953; -.
DR KEGG; fca:493953; -.
DR CTD; 3559; -.
DR VGNC; VGNC:67776; IL2RA.
DR eggNOG; ENOG502SUAG; Eukaryota.
DR GeneTree; ENSGT00390000018872; -.
DR HOGENOM; CLU_089677_1_0_1; -.
DR InParanoid; P41690; -.
DR OrthoDB; 1236351at2759; -.
DR TreeFam; TF337408; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000005794; Expressed in spleen and 4 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019976; F:interleukin-2 binding; IBA:GO_Central.
DR GO; GO:0004911; F:interleukin-2 receptor activity; IBA:GO_Central.
DR GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0006924; P:activation-induced cell death of T cells; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:2000561; P:regulation of CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl.
DR GO; GO:0002664; P:regulation of T cell tolerance induction; IEA:Ensembl.
DR CDD; cd00033; CCP; 1.
DR InterPro; IPR015486; IL-2_rcpt_alpha.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR10573; PTHR10573; 1.
DR Pfam; PF00084; Sushi; 1.
DR SMART; SM00032; CCP; 2.
DR SUPFAM; SSF57535; SSF57535; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Sushi; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..275
FT /note="Interleukin-2 receptor subunit alpha"
FT /id="PRO_0000011023"
FT TOPO_DOM 22..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..84
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 123..186
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 91..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..67
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 49..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 51..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 125..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 152..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 275 AA; 30817 MW; C97B8D8D06332326 CRC64;
MEPSLLLWGI LTFVVVHGHV TELCDENPPD IQHATFKALT YKTGTMLNCE CKKGFRRISN
GSAFMLCAGN SSHSSWENQC RCISTSPRAT DGQIIPKPEE QKGKSPMGMQ SQMQPTDQVN
LPGHCREPPP WEHEDSRRIY HFVVGQTVHY QCMQGFRALK RGPAKSVCKT TCGKATWTQP
RLQCLSERSD GWFPDDEEPQ ASTDAALGSD TSCPSITAST TDFQRHTEVA MTTESFVFTT
EYQIAVAGCV LLLISIVLLS GLTWQRRWRK SRRTI
