IL2RA_MOUSE
ID IL2RA_MOUSE Reviewed; 268 AA.
AC P01590; Q61731;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Interleukin-2 receptor subunit alpha;
DE Short=IL-2 receptor subunit alpha;
DE Short=IL-2-RA;
DE Short=IL-2R subunit alpha;
DE Short=IL2-RA;
DE AltName: Full=p55;
DE AltName: CD_antigen=CD25;
DE Flags: Precursor;
GN Name=Il2ra; Synonyms=Il2r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3921620;
RA Miller J., Malek T.R., Leonard W.J., Greene W.C., Shevach E.M.,
RA Germain R.N.;
RT "Nucleotide sequence and expression of a mouse interleukin 2 receptor
RT cDNA.";
RL J. Immunol. 134:4212-4217(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2987826; DOI=10.1093/nar/13.5.1505;
RA Shimuzu A., Kondo S., Takeda S., Yodoi J., Ishida N., Sabe H., Osawa H.,
RA Diamantstein T., Nikaido T., Honjo T.;
RT "Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with
RT the human IL-2 receptor sequence.";
RL Nucleic Acids Res. 13:1505-1516(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA McKereghan K.N., Alpert A.R., Grabstein K.H., Cosman D., Cerretti D.P.;
RT "Recombinant lymphokines and their receptors: molecular analysis for the
RT murine interleukin-2 receptor.";
RL Immunol. Ser. 35:109-123(1987).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-21.
RX PubMed=3135330;
RA Froussard P., Chastagner P., Somme G., Abadie A., Greene W., Theze J.,
RA Longacre S.;
RT "p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei.";
RL J. Immunol. 141:1358-1364(1988).
CC -!- FUNCTION: Receptor for interleukin-2. The receptor is involved in the
CC regulation of immune tolerance by controlling regulatory T cells
CC (TREGs) activity. TREGs suppress the activation and expansion of
CC autoreactive T-cells. {ECO:0000250|UniProtKB:P01589}.
CC -!- SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists
CC in 3 different forms: a high affinity dimer, an intermediate affinity
CC monomer (beta subunit), and a low affinity monomer (alpha subunit). The
CC high and intermediate affinity forms also associate with a gamma
CC subunit.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; K02891; AAA39285.1; -; mRNA.
DR EMBL; M30856; AAA39282.1; -; mRNA.
DR EMBL; M54934; AAA39290.1; -; mRNA.
DR EMBL; M21977; AAA39288.1; -; mRNA.
DR EMBL; M21978; AAA39287.1; -; mRNA.
DR CCDS; CCDS15685.1; -.
DR PIR; A01857; UHMS2.
DR RefSeq; NP_032393.3; NM_008367.3.
DR AlphaFoldDB; P01590; -.
DR SMR; P01590; -.
DR STRING; 10090.ENSMUSP00000028111; -.
DR BindingDB; P01590; -.
DR ChEMBL; CHEMBL3287; -.
DR GlyGen; P01590; 3 sites.
DR PhosphoSitePlus; P01590; -.
DR EPD; P01590; -.
DR PaxDb; P01590; -.
DR PRIDE; P01590; -.
DR ProteomicsDB; 301644; -.
DR Antibodypedia; 3715; 3086 antibodies from 52 providers.
DR DNASU; 16184; -.
DR Ensembl; ENSMUST00000028111; ENSMUSP00000028111; ENSMUSG00000026770.
DR GeneID; 16184; -.
DR KEGG; mmu:16184; -.
DR UCSC; uc008iiq.2; mouse.
DR CTD; 3559; -.
DR MGI; MGI:96549; Il2ra.
DR VEuPathDB; HostDB:ENSMUSG00000026770; -.
DR eggNOG; ENOG502SUAG; Eukaryota.
DR GeneTree; ENSGT00390000018872; -.
DR HOGENOM; CLU_089677_1_0_1; -.
DR InParanoid; P01590; -.
DR OMA; HYQCIQG; -.
DR OrthoDB; 1236351at2759; -.
DR PhylomeDB; P01590; -.
DR TreeFam; TF337408; -.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-9020558; Interleukin-2 signaling.
DR Reactome; R-MMU-912526; Interleukin receptor SHC signaling.
DR BioGRID-ORCS; 16184; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Il2ra; mouse.
DR PRO; PR:P01590; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P01590; protein.
DR Bgee; ENSMUSG00000026770; Expressed in thymus and 34 other tissues.
DR ExpressionAtlas; P01590; baseline and differential.
DR Genevisible; P01590; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019976; F:interleukin-2 binding; IPI:MGI.
DR GO; GO:0004911; F:interleukin-2 receptor activity; IMP:MGI.
DR GO; GO:0050798; P:activated T cell proliferation; IMP:MGI.
DR GO; GO:0006924; P:activation-induced cell death of T cells; IMP:MGI.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISO:MGI.
DR GO; GO:0046651; P:lymphocyte proliferation; IMP:MGI.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IMP:MGI.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IGI:MGI.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IMP:MGI.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; ISO:MGI.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:MGI.
DR GO; GO:2000561; P:regulation of CD4-positive, alpha-beta T cell proliferation; IMP:MGI.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IMP:MGI.
DR GO; GO:0002664; P:regulation of T cell tolerance induction; ISO:MGI.
DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI.
DR CDD; cd00033; CCP; 1.
DR InterPro; IPR015486; IL-2_rcpt_alpha.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR10573; PTHR10573; 1.
DR Pfam; PF00084; Sushi; 1.
DR SMART; SM00032; CCP; 2.
DR SUPFAM; SSF57535; SSF57535; 2.
DR PROSITE; PS50923; SUSHI; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Sushi; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT CHAIN 22..268
FT /note="Interleukin-2 receptor subunit alpha"
FT /id="PRO_0000011026"
FT TOPO_DOM 22..236
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..79
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 119..182
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 86..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 49..75
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 51..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 121..164
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 148..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CONFLICT 1..4
FT /note="MEPR -> MCQEDGAT (in Ref. 3; AAA39290)"
FT /evidence="ECO:0000305"
FT CONFLICT 7
FT /note="M -> T (in Ref. 2; AAA39282)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="T -> A (in Ref. 2; AAA39282)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="E -> V (in Ref. 2; AAA39282)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="F -> L (in Ref. 2; AAA39282)"
FT /evidence="ECO:0000305"
FT CONFLICT 227
FT /note="E -> V (in Ref. 2; AAA39282)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 30723 MW; 20C8F712B719192D CRC64;
MEPRLLMLGF LSLTIVPSCR AELCLYDPPE VPNATFKALS YKNGTILNCE CKRGFRRLKE
LVYMRCLGNS WSSNCQCTSN SHDKSRKQVT AQLEHQKEQQ TTTDMQKPTQ SMHQENLTGH
CREPPPWKHE DSKRIYHFVE GQSVHYECIP GYKALQRGPA ISICKMKCGK TGWTQPQLTC
VDEREHHRFL ASEESQGSRN SSPESETSCP ITTTDFPQPT ETTAMTETFV LTMEYKVAVA
SCLFLLISIL LLSGLTWQHR WRKSRRTI
