ID   APMAP_RAT               Reviewed;         376 AA.
AC   Q7TP48; Q3KR93;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Adipocyte plasma membrane-associated protein;
GN   Name=Apmap; ORFNames=Ab2-305;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Xu C.S., Li W.Q., Li Y.C., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P.,
RA   Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Shi J.B.,
RA   Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Exhibits strong arylesterase activity with beta-naphthyl
CC       acetate and phenyl acetate. May play a role in adipocyte
CC       differentiation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q7TP48-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7TP48-2; Sequence=VSP_036994, VSP_036995, VSP_036996;
CC   -!- SIMILARITY: Belongs to the strictosidine synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AY325201; AAP92602.1; -; mRNA.
DR   EMBL; BC105824; AAI05825.1; -; mRNA.
DR   RefSeq; NP_001029175.1; NM_001034003.1. [Q7TP48-1]
DR   RefSeq; XP_008760584.1; XM_008762362.2. [Q7TP48-1]
DR   AlphaFoldDB; Q7TP48; -.
DR   SMR; Q7TP48; -.
DR   GlyGen; Q7TP48; 1 site, 2 N-linked glycans (1 site).
DR   iPTMnet; Q7TP48; -.
DR   PhosphoSitePlus; Q7TP48; -.
DR   jPOST; Q7TP48; -.
DR   PRIDE; Q7TP48; -.
DR   GeneID; 366227; -.
DR   KEGG; rno:366227; -.
DR   UCSC; RGD:1308874; rat. [Q7TP48-1]
DR   CTD; 57136; -.
DR   RGD; 1308874; Apmap.
DR   VEuPathDB; HostDB:ENSRNOG00000006795; -.
DR   HOGENOM; CLU_023267_0_0_1; -.
DR   InParanoid; Q7TP48; -.
DR   PhylomeDB; Q7TP48; -.
DR   PRO; PR:Q7TP48; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000006795; Expressed in adult mammalian kidney and 19 other tissues.
DR   ExpressionAtlas; Q7TP48; baseline and differential.
DR   Genevisible; Q7TP48; RN.
DR   GO; GO:0009986; C:cell surface; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0004064; F:arylesterase activity; ISO:RGD.
DR   GO; GO:0016844; F:strictosidine synthase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018119; Strictosidine_synth_cons-reg.
DR   Pfam; PF03088; Str_synth; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..376
FT                   /note="Adipocyte plasma membrane-associated protein"
FT                   /id="PRO_0000370858"
FT   TRANSMEM        1..17
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        120
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         70
FT                   /note="D -> AVYWVTPLLWTQDSRSASVPVDVKH (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_036994"
FT   VAR_SEQ         198
FT                   /note="R -> RQVVVNVLKGWMYTGLCMSS (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_036995"
FT   VAR_SEQ         327..376
FT                   /note="VSDSGAFRRSLHDPDGQVVTYVSEAHEHDGYLYLGSFRSPFICRLSLQSI
FT                   -> PLTVVPSGEVCMILMDRWSPM (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_036996"
FT   CONFLICT        309
FT                   /note="F -> I (in Ref. 1; AAP92602)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        314
FT                   /note="V -> A (in Ref. 1; AAP92602)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   376 AA;  42062 MW;  023FF1B600C688C2 CRC64;
     MTFLMLAVSL AIPLLGAMML LESPIDPQSF SFKEPPFMFG VLQPNTKLRQ AERLFENQLN
     GPESIVNIGD VLFTGTADGR VVKLENGEIE TIARFGSGPC KTRDDEPTCG RPLGIRVGPN
     GTLFVVDAYK GLFEVNPQKR SVKLLLSSET PIEGKKMSFV NDLTITRDGR KIYFTDSSSK
     WQRRDYLLLV MEGTDDGRLL EYDTVTKEVK VLLDQLQFPN GVQLSPEEDF VLVAETAMAR
     IRRVYVSGLM KGGADMFVEN MPGFPDNIRP SSSGGYWVAA ATIRANPGFS MLDFLSDKPF
     IKRMIFKLFS QETVMKFVPR YSLVLEVSDS GAFRRSLHDP DGQVVTYVSE AHEHDGYLYL
     GSFRSPFICR LSLQSI