IL2RG_BOVIN
ID IL2RG_BOVIN Reviewed; 379 AA.
AC Q95118; A7YW94;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Cytokine receptor common subunit gamma;
DE AltName: Full=Interleukin-2 receptor subunit gamma;
DE Short=IL-2 receptor subunit gamma;
DE Short=IL-2R subunit gamma;
DE Short=IL-2RG;
DE AltName: Full=gammaC;
DE AltName: Full=p64;
DE AltName: CD_antigen=CD132;
DE Flags: Precursor;
GN Name=IL2RG;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8672241; DOI=10.1089/dna.1996.15.453;
RA Yoo J., Stone R.T., Solinas-Toldo S., Fries R., Beattie C.W.;
RT "Cloning and chromosomal mapping of bovine interleukin-2 receptor gamma
RT gene.";
RL DNA Cell Biol. 15:453-459(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Common subunit for the receptors for a variety of
CC interleukins. Probably in association with IL15RA, involved in the
CC stimulation of neutrophil phagocytosis by IL15 (By similarity).
CC {ECO:0000250|UniProtKB:P31785}.
CC -!- SUBUNIT: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21
CC and probably also the IL13 receptors. Interacts with SHB upon
CC interleukin stimulation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31785};
CC Single-pass type I membrane protein {ECO:0000255}. Cell surface
CC {ECO:0000250|UniProtKB:P31785}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U33748; AAB07812.1; -; Genomic_DNA.
DR EMBL; BC134467; AAI34468.1; -; mRNA.
DR RefSeq; NP_776784.1; NM_174359.1.
DR AlphaFoldDB; Q95118; -.
DR SMR; Q95118; -.
DR STRING; 9913.ENSBTAP00000010033; -.
DR PaxDb; Q95118; -.
DR PRIDE; Q95118; -.
DR Ensembl; ENSBTAT00000010033; ENSBTAP00000010033; ENSBTAG00000007626.
DR GeneID; 281862; -.
DR KEGG; bta:281862; -.
DR CTD; 3561; -.
DR VEuPathDB; HostDB:ENSBTAG00000007626; -.
DR VGNC; VGNC:30153; IL2RG.
DR eggNOG; ENOG502S289; Eukaryota.
DR GeneTree; ENSGT00510000048979; -.
DR HOGENOM; CLU_060544_1_0_1; -.
DR InParanoid; Q95118; -.
DR OMA; NKDTSWT; -.
DR OrthoDB; 753404at2759; -.
DR TreeFam; TF333657; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000007626; Expressed in blood and 104 other tissues.
DR ExpressionAtlas; Q95118; baseline and differential.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0042010; F:interleukin-15 receptor activity; ISS:UniProtKB.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein;
KW Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..379
FT /note="Cytokine receptor common subunit gamma"
FT /id="PRO_0000010864"
FT TOPO_DOM 23..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 163..260
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 349..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 244..248
FT /note="WSXWS motif"
FT MOTIF 299..307
FT /note="Box 1 motif"
FT MOD_RES 305
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P31785"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 68..78
FT /evidence="ECO:0000255"
FT DISULFID 109..122
FT /evidence="ECO:0000255"
SQ SEQUENCE 379 AA; 43038 MW; 33CFAD9C9B032178 CRC64;
MLKPPLPLRS LLFLQLPLLG VGLNPKFLTP SGNEDIGGKP GTGGDFFLTS TPAGTLDVST
LPLPKVQCFV FNVEYMNCTW NSSSEPQPNN LTLHYGYRNF NGDDKLQECG HYLFSEGITS
GCWFGKKEIR LYETFVVQLQ DPREHRKQPK QMLKLQDLVI PWAPENLTLR NLSEFQLELS
WSNRYLDHCL EHLVQYRSDR DRSWTEQSVD HRHSFSLPSV DAQKLYTFRV RSRYNPLCGS
AQHWSDWSYP IHWGSNTSKE NIENPENPSL FALEAVLIPL GSMGLIVSLI CVYCWLERTM
PRIPTLKNLE DLVTEYQGNF SAWSGVSKGL AESLQPDYSE RLCHVSEIPP KGGEGPGGSP
CSQHSPYWAP PCYTLKPEP
