ID   IL2_FELCA               Reviewed;         154 AA.
AC   Q07885;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Interleukin-2;
DE            Short=IL-2;
DE   AltName: Full=T-cell growth factor;
DE            Short=TCGF;
DE   Flags: Precursor;
GN   Name=IL2;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8352761; DOI=10.1006/bbrc.1993.1926;
RA   Cozzi P.J., Padrid P.A., Takeda J., Alegre M.-A., Yuhki N., Leff A.R.;
RT   "Sequence and functional characterization of feline interleukin 2.";
RL   Biochem. Biophys. Res. Commun. 194:1038-1043(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Litman R., Gibbs C., Good R.A., Day N.K.;
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine produced by activated CD4-positive helper T-cells
CC       and to a lesser extend activated CD8-positive T-cells and natural
CC       killer (NK) cells that plays pivotal roles in the immune response and
CC       tolerance. Binds to a receptor complex composed of either the high-
CC       affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or
CC       the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the
CC       receptor leads to oligomerization and conformation changes in the IL-2R
CC       subunits resulting in downstream signaling starting with
CC       phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate
CC       the receptor to form a docking site leading to the phosphorylation of
CC       several substrates including STAT5. This process leads to activation of
CC       several pathways including STAT, phosphoinositide-3-kinase/PI3K and
CC       mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell
CC       growth factor and can increase NK-cell cytolytic activity as well.
CC       Promotes strong proliferation of activated B-cells and subsequently
CC       immunoglobulin production. Plays a pivotal role in regulating the
CC       adaptive immune system by controlling the survival and proliferation of
CC       regulatory T-cells, which are required for the maintenance of immune
CC       tolerance. Moreover, participates in the differentiation and
CC       homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as
CC       well as memory CD8-positive T-cells. {ECO:0000250|UniProtKB:P60568}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
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DR   EMBL; L19402; AAA02865.1; -; mRNA.
DR   EMBL; L25408; AAA51431.1; -; mRNA.
DR   PIR; JN0698; JN0698.
DR   RefSeq; NP_001036802.1; NM_001043337.1.
DR   AlphaFoldDB; Q07885; -.
DR   SMR; Q07885; -.
DR   STRING; 9685.ENSFCAP00000012696; -.
DR   Ensembl; ENSFCAT00000013692; ENSFCAP00000012696; ENSFCAG00000013688.
DR   Ensembl; ENSFCAT00000055869; ENSFCAP00000042708; ENSFCAG00000013688.
DR   Ensembl; ENSFCAT00000057802; ENSFCAP00000047381; ENSFCAG00000013688.
DR   GeneID; 751114; -.
DR   KEGG; fca:751114; -.
DR   CTD; 3558; -.
DR   VGNC; VGNC:78516; IL2.
DR   eggNOG; ENOG502RVR5; Eukaryota.
DR   GeneTree; ENSGT00390000003555; -.
DR   HOGENOM; CLU_124210_0_0_1; -.
DR   InParanoid; Q07885; -.
DR   OMA; NGVNNYE; -.
DR   OrthoDB; 947117at2759; -.
DR   TreeFam; TF338200; -.
DR   Proteomes; UP000011712; Chromosome B1.
DR   Bgee; ENSFCAG00000013688; Expressed in spleen.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
DR   GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0002366; P:leukocyte activation involved in immune response; IEA:Ensembl.
DR   GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR   GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IEA:Ensembl.
DR   GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR   GO; GO:1900100; P:positive regulation of plasma cell differentiation; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:2000561; P:regulation of CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR   GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000779; IL-2.
DR   InterPro; IPR030477; IL-2_CS.
DR   Pfam; PF00715; IL2; 1.
DR   PRINTS; PR00265; INTERLEUKIN2.
DR   SMART; SM00189; IL2; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00424; INTERLEUKIN_2; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW   Immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..154
FT                   /note="Interleukin-2"
FT                   /id="PRO_0000015481"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        78..126
FT                   /evidence="ECO:0000250"
FT   CONFLICT        3..4
FT                   /note="KI -> RM (in Ref. 2; AAA51431)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="F -> I (in Ref. 2; AAA51431)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   154 AA;  17654 MW;  2E71E3BD8B9665EF CRC64;
     MYKIQLLSCI ALTLILVTNS APASSSTKET QQQLEQLLLD LRLLLNGVNN PENPKLSRML
     TFKFYVPKKA TELTHLQCLV EELKPLEEVL YLAQSKNFHL NHIKELMSNI NVTVLKLKGS
     ETRFTCNYDD ETATIVEFLN KWITFCQSIF STLT