ID   IL2_MUSSP               Reviewed;         166 AA.
AC   Q08867; P70462; P70463;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Interleukin-2;
DE            Short=IL-2;
DE   AltName: Full=T-cell growth factor;
DE            Short=TCGF;
DE   Flags: Precursor;
GN   Name=Il2;
OS   Mus spretus (Western Mediterranean mouse) (Algerian mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10096;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-60.
RC   STRAIN=SPRET/EI;
RX   PubMed=8319981; DOI=10.1007/bf00188809;
RA   Matesanz F., Alcina A., Pellicer A.;
RT   "Existence of at least five interleukin-2 molecules in different mouse
RT   strains.";
RL   Immunogenetics 38:300-303(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 21-166.
RC   STRAIN=SPRET/EI;
RX   PubMed=8765005; DOI=10.1002/eji.1830260802;
RA   Matesanz F., Alcina A.;
RT   "Glutamine and tetrapeptide repeat variations affect the biological
RT   activity of different mouse interleukin-2 alleles.";
RL   Eur. J. Immunol. 26:1675-1682(1996).
CC   -!- FUNCTION: Cytokine produced by activated CD4-positive helper T-cells
CC       and to a lesser extend activated CD8-positive T-cells and natural
CC       killer (NK) cells that plays pivotal roles in the immune response and
CC       tolerance. Binds to a receptor complex composed of either the high-
CC       affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or
CC       the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the
CC       receptor leads to oligomerization and conformation changes in the IL-2R
CC       subunits resulting in downstream signaling starting with
CC       phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate
CC       the receptor to form a docking site leading to the phosphorylation of
CC       several substrates including STAT5. This process leads to activation of
CC       several pathways including STAT, phosphoinositide-3-kinase/PI3K and
CC       mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell
CC       growth factor and can increase NK-cell cytolytic activity as well.
CC       Promotes strong proliferation of activated B-cells and subsequently
CC       immunoglobulin production. Plays a pivotal role in regulating the
CC       adaptive immune system by controlling the survival and proliferation of
CC       regulatory T-cells, which are required for the maintenance of immune
CC       tolerance. Moreover, participates in the differentiation and
CC       homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as
CC       well as memory CD8-positive T-cells. {ECO:0000250|UniProtKB:P60568}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
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DR   EMBL; L07575; AAA39327.1; -; Genomic_DNA.
DR   EMBL; U41398; AAB39205.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U41495; AAB39207.1; ALT_SEQ; mRNA.
DR   PIR; I68870; I68870.
DR   AlphaFoldDB; Q08867; -.
DR   SMR; Q08867; -.
DR   MGI; MGI:96548; Il2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005134; F:interleukin-2 receptor binding; IEA:InterPro.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000779; IL-2.
DR   InterPro; IPR030477; IL-2_CS.
DR   Pfam; PF00715; IL2; 1.
DR   PRINTS; PR00265; INTERLEUKIN2.
DR   SMART; SM00189; IL2; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00424; INTERLEUKIN_2; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW   Immunity; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..166
FT                   /note="Interleukin-2"
FT                   /id="PRO_0000015494"
FT   CARBOHYD        23
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..137
FT                   /evidence="ECO:0000250"
FT   VARIANT         24..27
FT                   /note="Missing"
SQ   SEQUENCE   166 AA;  18763 MW;  C11056E29E386ABB CRC64;
     MYSMQLASCV TLTLVLLVNS APTSSPTSSS TSSSTAEAQQ QQQHLEQLLM DLQELLSRME
     NYRNLKLPRM LTFKFYLPKQ ATELKDLQCL EDELGPLQSV LDLTQSKSFQ LEDAENFISN
     IRVTVVKLKG SDNTIECQFD DESATVVDFL RRWIAFCQSI ISTSPQ