IL2_PIG
ID IL2_PIG Reviewed; 154 AA.
AC P26891;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Interleukin-2;
DE Short=IL-2;
DE AltName: Full=T-cell growth factor;
DE Short=TCGF;
DE Flags: Precursor;
GN Name=IL2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RX PubMed=2054386; DOI=10.1016/0167-4781(91)90019-i;
RA Goodall J.C., Emery D.C., Bailey M., English L.S., Hall L.;
RT "cDNA cloning of porcine interleukin 2 by polymerase chain reaction.";
RL Biochim. Biophys. Acta 1089:257-258(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=T-cell;
RA Lefevre F.;
RL Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Iwata H., Hasegawa A., Yamamoto M., Oida T., Endo Y., Inoue T.;
RT "Structure of the porcine chromosomal interleukin-2 gene.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RA Gao R., Li H., Wang L., Wu M., Liu S.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine produced by activated CD4-positive helper T-cells
CC and to a lesser extend activated CD8-positive T-cells and natural
CC killer (NK) cells that plays pivotal roles in the immune response and
CC tolerance. Binds to a receptor complex composed of either the high-
CC affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or
CC the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the
CC receptor leads to oligomerization and conformation changes in the IL-2R
CC subunits resulting in downstream signaling starting with
CC phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate
CC the receptor to form a docking site leading to the phosphorylation of
CC several substrates including STAT5. This process leads to activation of
CC several pathways including STAT, phosphoinositide-3-kinase/PI3K and
CC mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell
CC growth factor and can increase NK-cell cytolytic activity as well.
CC Promotes strong proliferation of activated B-cells and subsequently
CC immunoglobulin production. Plays a pivotal role in regulating the
CC adaptive immune system by controlling the survival and proliferation of
CC regulatory T-cells, which are required for the maintenance of immune
CC tolerance. Moreover, participates in the differentiation and
CC homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as
CC well as memory CD8-positive T-cells. {ECO:0000250|UniProtKB:P60568}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
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DR EMBL; X56750; CAA40071.1; -; mRNA.
DR EMBL; X58428; CAA41330.1; -; mRNA.
DR EMBL; AB041935; BAB16110.1; -; Genomic_DNA.
DR EMBL; AY294018; AAP72169.1; -; mRNA.
DR PIR; S16241; S16241.
DR RefSeq; NP_999026.1; NM_213861.1.
DR AlphaFoldDB; P26891; -.
DR SMR; P26891; -.
DR STRING; 9823.ENSSSCP00000009697; -.
DR PaxDb; P26891; -.
DR Ensembl; ENSSSCT00000047936; ENSSSCP00000059176; ENSSSCG00000033267.
DR Ensembl; ENSSSCT00005061255; ENSSSCP00005037875; ENSSSCG00005038311.
DR Ensembl; ENSSSCT00060049790; ENSSSCP00060021302; ENSSSCG00060036746.
DR Ensembl; ENSSSCT00065049281; ENSSSCP00065021326; ENSSSCG00065036141.
DR Ensembl; ENSSSCT00070046371; ENSSSCP00070039119; ENSSSCG00070023270.
DR Ensembl; ENSSSCT00070046374; ENSSSCP00070039121; ENSSSCG00070023270.
DR GeneID; 396868; -.
DR KEGG; ssc:396868; -.
DR CTD; 3558; -.
DR VGNC; VGNC:98935; IL2.
DR eggNOG; ENOG502RVR5; Eukaryota.
DR GeneTree; ENSGT00390000003555; -.
DR HOGENOM; CLU_124210_0_0_1; -.
DR InParanoid; P26891; -.
DR OMA; NGVNNYE; -.
DR OrthoDB; 1491449at2759; -.
DR TreeFam; TF338200; -.
DR Proteomes; UP000008227; Chromosome 8.
DR Proteomes; UP000314985; Chromosome 8.
DR Bgee; ENSSSCG00000033267; Expressed in tonsil and 14 other tissues.
DR ExpressionAtlas; P26891; baseline.
DR Genevisible; P26891; SS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
DR GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0002366; P:leukocyte activation involved in immune response; IEA:Ensembl.
DR GO; GO:0002903; P:negative regulation of B cell apoptotic process; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IEA:Ensembl.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
DR GO; GO:1900100; P:positive regulation of plasma cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:2000561; P:regulation of CD4-positive, alpha-beta T cell proliferation; IEA:Ensembl.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000779; IL-2.
DR InterPro; IPR030477; IL-2_CS.
DR Pfam; PF00715; IL2; 1.
DR PRINTS; PR00265; INTERLEUKIN2.
DR SMART; SM00189; IL2; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00424; INTERLEUKIN_2; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..154
FT /note="Interleukin-2"
FT /id="PRO_0000015498"
FT CARBOHYD 23
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT DISULFID 78..126
FT /evidence="ECO:0000250"
SQ SEQUENCE 154 AA; 17401 MW; F3B95E43D4A3D3E1 CRC64;
MYKMQLLCCI ALTLALMANG APTSSSTKNT KKQLEPLLLD LQLLLKEVKN YENADLSRML
TFKFYMPKQA TELKHLQCLV EELKALEGVL NLGQSKNSDS ANIKESMNNI NVTVLELKGS
ETSFKCEYDD ETVTAVEFLN KWITFCQSIY STLT
