IL2_RAT
ID IL2_RAT Reviewed; 155 AA.
AC P17108;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Interleukin-2;
DE Short=IL-2;
DE AltName: Full=T-cell growth factor;
DE Short=TCGF;
DE Flags: Precursor;
GN Name=Il2; Synonyms=Il-2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2788130; DOI=10.1007/bf02421547;
RA McKnight A.J., Mason D.W., Barclay A.N.;
RT "Sequence of rat interleukin 2 and anomalous binding of a mouse interleukin
RT 2 cDNA probe to rat MHC class II-associated invariant chain mRNA.";
RL Immunogenetics 30:145-147(1989).
CC -!- FUNCTION: Cytokine produced by activated CD4-positive helper T-cells
CC and to a lesser extend activated CD8-positive T-cells and natural
CC killer (NK) cells that plays pivotal roles in the immune response and
CC tolerance. Binds to a receptor complex composed of either the high-
CC affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or
CC the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the
CC receptor leads to oligomerization and conformation changes in the IL-2R
CC subunits resulting in downstream signaling starting with
CC phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate
CC the receptor to form a docking site leading to the phosphorylation of
CC several substrates including STAT5. This process leads to activation of
CC several pathways including STAT, phosphoinositide-3-kinase/PI3K and
CC mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell
CC growth factor and can increase NK-cell cytolytic activity as well.
CC Promotes strong proliferation of activated B-cells and subsequently
CC immunoglobulin production. Plays a pivotal role in regulating the
CC adaptive immune system by controlling the survival and proliferation of
CC regulatory T-cells, which are required for the maintenance of immune
CC tolerance. Moreover, participates in the differentiation and
CC homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as
CC well as memory CD8-positive T-cells. {ECO:0000250|UniProtKB:P60568}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000305}.
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DR EMBL; M22899; AAA41427.1; -; mRNA.
DR PIR; A45882; A31278.
DR RefSeq; NP_446288.1; NM_053836.1.
DR AlphaFoldDB; P17108; -.
DR SMR; P17108; -.
DR STRING; 10116.ENSRNOP00000023327; -.
DR GlyGen; P17108; 1 site.
DR PaxDb; P17108; -.
DR Ensembl; ENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348.
DR GeneID; 116562; -.
DR KEGG; rno:116562; -.
DR UCSC; RGD:620047; rat.
DR CTD; 3558; -.
DR RGD; 620047; Il2.
DR eggNOG; ENOG502RVR5; Eukaryota.
DR GeneTree; ENSGT00390000003555; -.
DR HOGENOM; CLU_124210_0_0_1; -.
DR InParanoid; P17108; -.
DR OMA; NGVNNYE; -.
DR OrthoDB; 1491449at2759; -.
DR PhylomeDB; P17108; -.
DR TreeFam; TF338200; -.
DR PRO; PR:P17108; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000017348; Expressed in ileum and 5 other tissues.
DR Genevisible; P17108; RN.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0030246; F:carbohydrate binding; IDA:RGD.
DR GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR GO; GO:0043208; F:glycosphingolipid binding; IDA:RGD.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IMP:RGD.
DR GO; GO:0031851; F:kappa-type opioid receptor binding; IMP:RGD.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0010467; P:gene expression; ISO:RGD.
DR GO; GO:0002366; P:leukocyte activation involved in immune response; ISO:RGD.
DR GO; GO:0002903; P:negative regulation of B cell apoptotic process; ISO:RGD.
DR GO; GO:0045822; P:negative regulation of heart contraction; IDA:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISO:RGD.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IDA:RGD.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; ISO:RGD.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISO:RGD.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0060999; P:positive regulation of dendritic spine development; IDA:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:RGD.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISO:RGD.
DR GO; GO:1900100; P:positive regulation of plasma cell differentiation; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IDA:RGD.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IMP:RGD.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; ISO:RGD.
DR GO; GO:0045471; P:response to ethanol; IDA:RGD.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000779; IL-2.
DR InterPro; IPR030477; IL-2_CS.
DR Pfam; PF00715; IL2; 1.
DR PRINTS; PR00265; INTERLEUKIN2.
DR SMART; SM00189; IL2; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00424; INTERLEUKIN_2; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..155
FT /note="Interleukin-2"
FT /id="PRO_0000015500"
FT CARBOHYD 23
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT DISULFID 78..126
FT /evidence="ECO:0000250|UniProtKB:P60568"
SQ SEQUENCE 155 AA; 17633 MW; 67A8554A73BF30A0 CRC64;
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML
TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS
ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ
