IL31R_MOUSE
ID IL31R_MOUSE Reviewed; 716 AA.
AC Q8K5B1; E9QQ31; Q6EAL6; Q6EAL7; Q6NZF0; Q8BSU3; Q8R501;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Interleukin-31 receptor subunit alpha;
DE Short=IL-31 receptor subunit alpha;
DE Short=IL-31R subunit alpha;
DE Short=IL-31R-alpha;
DE Short=IL-31RA;
DE AltName: Full=GLM-R;
DE Short=mGLM-R;
DE AltName: Full=Gp130-like monocyte receptor;
DE Short=Gp130-like receptor;
DE AltName: Full=Novel cytokine receptor 10;
DE Short=NR10;
DE AltName: Full=ZcytoR17;
DE Flags: Precursor;
GN Name=Il31ra; Synonyms=Glmr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=11877449; DOI=10.1074/jbc.m201140200;
RA Ghilardi N., Li J., Hongo J.-A., Yi S., Gurney A., De Sauvage F.J.;
RT "A novel type I cytokine receptor is expressed on monocytes, signals
RT proliferation, and activates STAT-3 and STAT-5.";
RL J. Biol. Chem. 277:16831-16836(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION, INDUCTION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=15184896; DOI=10.1038/ni1084;
RA Dillon S.R., Sprecher C., Hammond A., Bilsborough J.,
RA Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B.,
RA Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P.,
RA Dong D.L., Dasovich M., Grant F.J., Lockwood L., Levin S.D., LeCiel C.,
RA Waggie K., Day H., Topouzis S., Kramer J., Kuestner R., Chen Z., Foster D.,
RA Parrish-Novak J., Gross J.A.;
RT "Interleukin 31, a cytokine produced by activated T cells, induces
RT dermatitis in mice.";
RL Nat. Immunol. 5:752-760(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RA Nomura H., Yaguchi N., Maeda M., Hasegawa M.;
RT "Polymorphism between C57BL/6 and Balb/c in the novel cytokine receptor
RT NR10.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16926070; DOI=10.1016/j.neuroscience.2006.07.009;
RA Bando T., Morikawa Y., Komori T., Senba E.;
RT "Complete overlap of interleukin-31 receptor A and oncostatin M receptor
RT beta in the adult dorsal root ganglia with distinct developmental
RT expression patterns.";
RL Neuroscience 142:1263-1271(2006).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17379091; DOI=10.1016/j.exphem.2007.01.028;
RA Broxmeyer H.E., Li J., Hangoc G., Cooper S., Tao W., Mantel C.,
RA Graham-Evans B., Ghilardi N., de Sauvage F.J.;
RT "Regulation of myeloid progenitor cell proliferation/survival by IL-31
RT receptor and IL-31.";
RL Exp. Hematol. 35:78-86(2007).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=24373353; DOI=10.1016/j.jaci.2013.10.048;
RA Cevikbas F., Wang X., Akiyama T., Kempkes C., Savinko T., Antal A.,
RA Kukova G., Buhl T., Ikoma A., Buddenkotte J., Soumelis V., Feld M.,
RA Alenius H., Dillon S.R., Carstens E., Homey B., Basbaum A., Steinhoff M.;
RT "A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent
RT itch: Involvement of TRPV1 and TRPA1.";
RL J. Allergy Clin. Immunol. 133:448-460(2014).
RN [10]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=25381841; DOI=10.1111/exd.12587;
RA Arai I., Tsuji M., Miyagawa K., Takeda H., Akiyama N., Saito S.;
RT "Repeated administration of IL-31 upregulates IL-31 receptor A (IL-31RA) in
RT dorsal root ganglia and causes severe itch-associated scratching behaviour
RT in mice.";
RL Exp. Dermatol. 24:75-78(2015).
RN [11]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=25847241; DOI=10.1074/jbc.m114.622126;
RA Edukulla R., Singh B., Jegga A.G., Sontake V., Dillon S.R., Madala S.K.;
RT "Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-
RT 31RA Expression.";
RL J. Biol. Chem. 290:13510-13520(2015).
CC -!- FUNCTION: Associates with OSMR to form the interleukin-31 receptor
CC which activates STAT3 and to a lower extent STAT1 and STAT5. May
CC function in skin immunity (PubMed:15184896). Mediates IL31-induced
CC itch, probably in a manner dependent on cation channels TRPA1 and TRPV1
CC (PubMed:24373353). Positively regulates numbers and cycling status of
CC immature subsets of myeloid progenitor cells in bone marrow in vivo and
CC enhances myeloid progenitor cell survival in vitro (PubMed:17379091).
CC {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:17379091,
CC ECO:0000269|PubMed:24373353}.
CC -!- SUBUNIT: Heterodimer with OSMR. Interacts with JAK1 and STAT3.
CC {ECO:0000250|UniProtKB:Q8NI17}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25847241};
CC Single-pass type I membrane protein {ECO:0000305}. Presynaptic cell
CC membrane {ECO:0000269|PubMed:25381841}. Cell projection, axon
CC {ECO:0000269|PubMed:25381841}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8K5B1-1; Sequence=Displayed;
CC Name=2; Synonyms=muZcytoR17x1;
CC IsoId=Q8K5B1-2; Sequence=VSP_022815, VSP_022821, VSP_022822;
CC Name=3; Synonyms=muZcytoR17x2;
CC IsoId=Q8K5B1-3; Sequence=VSP_022815, VSP_022819, VSP_022820;
CC Name=4;
CC IsoId=Q8K5B1-4; Sequence=VSP_022816, VSP_022817, VSP_022818;
CC Name=5;
CC IsoId=Q8K5B1-5; Sequence=VSP_022814;
CC -!- TISSUE SPECIFICITY: Expressed in a subset of dorsal root ganglia
CC neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed
CC in spinal cord and trigeminal ganglion (at protein level)
CC (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus
CC (PubMed:15184896). {ECO:0000269|PubMed:15184896,
CC ECO:0000269|PubMed:16926070, ECO:0000269|PubMed:24373353,
CC ECO:0000269|PubMed:25381841}.
CC -!- DEVELOPMENTAL STAGE: Primarily expressed at postnatal day 10 in the
CC dorsal root ganglia where expression gradually increases as the
CC development proceed. {ECO:0000269|PubMed:16926070}.
CC -!- INDUCTION: Up-regulated in the diseased tissues of a mouse models of
CC allergic asthma and airway hypersensitivity (PubMed:15184896,
CC PubMed:25847241). Up-regulated by IL31 in dorsal root ganglia
CC (PubMed:25381841). Up-regulated by Th2 cytokines IL4 and IL13 in
CC macrophages (PubMed:25847241). {ECO:0000269|PubMed:15184896,
CC ECO:0000269|PubMed:25381841, ECO:0000269|PubMed:25847241}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8NI17}.
CC -!- DISRUPTION PHENOTYPE: Mice do not develop dermatitis upon Il31
CC overexpression (PubMed:15184896). Decreased levels of immature myeloid
CC progenitor cells in bone marrow and spleen but normal numbers of
CC circulating blood cells (PubMed:17379091).
CC {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:17379091}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000305}.
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DR EMBL; AF486621; AAM27959.1; -; mRNA.
DR EMBL; AY509150; AAS82847.1; -; mRNA.
DR EMBL; AY509151; AAS82848.1; -; mRNA.
DR EMBL; AB083111; BAB88745.1; -; mRNA.
DR EMBL; AK030512; BAC26998.1; -; mRNA.
DR EMBL; AC154767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC159196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066164; AAH66164.1; -; mRNA.
DR CCDS; CCDS36781.1; -. [Q8K5B1-1]
DR RefSeq; NP_647460.2; NM_139299.2. [Q8K5B1-1]
DR RefSeq; XP_006517684.1; XM_006517621.2. [Q8K5B1-1]
DR RefSeq; XP_017170988.1; XM_017315499.1. [Q8K5B1-1]
DR AlphaFoldDB; Q8K5B1; -.
DR SMR; Q8K5B1; -.
DR STRING; 10090.ENSMUSP00000058045; -.
DR GlyGen; Q8K5B1; 4 sites.
DR iPTMnet; Q8K5B1; -.
DR PhosphoSitePlus; Q8K5B1; -.
DR PaxDb; Q8K5B1; -.
DR PRIDE; Q8K5B1; -.
DR ProteomicsDB; 267041; -. [Q8K5B1-1]
DR ProteomicsDB; 267042; -. [Q8K5B1-2]
DR ProteomicsDB; 267043; -. [Q8K5B1-3]
DR ProteomicsDB; 267044; -. [Q8K5B1-4]
DR Antibodypedia; 23449; 278 antibodies from 26 providers.
DR DNASU; 218624; -.
DR Ensembl; ENSMUST00000051756; ENSMUSP00000058045; ENSMUSG00000050377. [Q8K5B1-1]
DR GeneID; 218624; -.
DR KEGG; mmu:218624; -.
DR UCSC; uc007rwi.2; mouse. [Q8K5B1-1]
DR UCSC; uc007rwj.1; mouse. [Q8K5B1-3]
DR CTD; 133396; -.
DR MGI; MGI:2180511; Il31ra.
DR VEuPathDB; HostDB:ENSMUSG00000050377; -.
DR eggNOG; ENOG502QVZY; Eukaryota.
DR GeneTree; ENSGT00940000155603; -.
DR HOGENOM; CLU_017990_2_0_1; -.
DR InParanoid; Q8K5B1; -.
DR OMA; ILQYDLE; -.
DR OrthoDB; 144839at2759; -.
DR PhylomeDB; Q8K5B1; -.
DR TreeFam; TF338122; -.
DR Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
DR BioGRID-ORCS; 218624; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Il31ra; mouse.
DR PRO; PR:Q8K5B1; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8K5B1; protein.
DR Bgee; ENSMUSG00000050377; Expressed in lumbar dorsal root ganglion and 32 other tissues.
DR ExpressionAtlas; Q8K5B1; baseline and differential.
DR Genevisible; Q8K5B1; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IPI:MGI.
DR GO; GO:0004896; F:cytokine receptor activity; ISO:MGI.
DR GO; GO:0051916; F:granulocyte colony-stimulating factor binding; IBA:GO_Central.
DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IMP:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0098542; P:defense response to other organism; IMP:MGI.
DR GO; GO:0002067; P:glandular epithelial cell differentiation; IMP:MGI.
DR GO; GO:0030224; P:monocyte differentiation; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISS:UniProtKB.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; -; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; SSF49265; 3.
DR PROSITE; PS50853; FN3; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cell projection; Glycoprotein;
KW Immunity; Membrane; Receptor; Reference proteome; Repeat; Signal; Synapse;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000250"
FT CHAIN 19..716
FT /note="Interleukin-31 receptor subunit alpha"
FT /id="PRO_0000274573"
FT TOPO_DOM 19..499
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 521..716
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..115
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 117..211
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 213..304
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 305..403
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 408..502
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 622..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..481
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022814"
FT VAR_SEQ 1
FT /note="M -> MLSSQKGSCSQEPGAAHVQPLGVNAGIM (in isoform 2 and
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15184896"
FT /id="VSP_022815"
FT VAR_SEQ 1
FT /note="M -> MNPLGVNAGIM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022816"
FT VAR_SEQ 463..482
FT /note="ALQCDLESLTRRTSYTVWVM -> SPQVYYALTAAKSRNSRNLQ (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022817"
FT VAR_SEQ 483..716
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022818"
FT VAR_SEQ 504..520
FT /note="VFEIVLLTSLVGGGLLL -> EYWLQASFWSLLRVGNV (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15184896"
FT /id="VSP_022819"
FT VAR_SEQ 521..716
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15184896"
FT /id="VSP_022820"
FT VAR_SEQ 624..635
FT /note="VTSPSRPDGPPG -> ILSQEPSCPGHC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15184896"
FT /id="VSP_022821"
FT VAR_SEQ 636..716
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15184896"
FT /id="VSP_022822"
FT CONFLICT 159
FT /note="H -> R (in Ref. 1; AAM27959, 2; AAS82847/AAS82848
FT and 3; BAB88745)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="A -> T (in Ref. 1; AAM27959 and 2; AAS82847/
FT AAS82848)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="K -> Q (in Ref. 1; AAM27959 and 2; AAS82847/
FT AAS82848)"
FT /evidence="ECO:0000305"
FT CONFLICT 573
FT /note="D -> N (in Ref. 1; AAM27959 and 2; AAS82847)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="V -> I (in Ref. 1; AAM27959)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 716 AA; 80580 MW; 21A539EDCCD1FEFD CRC64;
MWTLALWAFS FLCKFSLAVL PTKPENISCV FYFDRNLTCT WRPEKETNDT SYIVTLTYSY
GKSNYSDNAT EASYSFPRSC AMPPDICSVE VQAQNGDGKV KSDITYWHLI SIAKTEPPII
LSVNPICNRM FQIQWKPREK TRGFPLVCML RFRTVNSSHW TEVNFENCKQ VCNLTGLQAF
TEYVLALRFR FNDSRYWSKW SKEETRVTME EVPHVLDLWR ILEPADMNGD RKVRLLWKKA
RGAPVLEKTF GYHIQYFAEN STNLTEINNI TTQQYELLLM SQAHSVSVTS FNSLGKSQEA
ILRIPDVHEK TFQYIKSMKA YIAEPLLVVN WQSSIPAVDT WIVEWLPEAA MSKFPALSWE
SVSQVTNWTI EQDKLKPFTC YNISVYPVLG HRVGEPYSIQ AYAKEGTPLK GPETRVENIG
LRTATITWKE IPKSARNGFI NNYTVFYQAE GGKELSKTVN SHALQCDLES LTRRTSYTVW
VMASTRAGGT NGVRINFKTL SISVFEIVLL TSLVGGGLLL LSIKTVTFGL RKPNRLTPLC
CPDVPNPAES SLATWLGDGF KKSNMKETGN SGDTEDVVLK PCPVPADLID KLVVNFENFL
EVVLTEEAGK GQASILGGEA NEYVTSPSRP DGPPGKSFKE PSVLTEVASE DSHSTCSRMA
DEAYSELARQ PSSSCQSPGL SPPREDQAQN PYLKNSVTTR EFLVHENIPE HSKGEV
