IL31_HUMAN
ID IL31_HUMAN Reviewed; 164 AA.
AC Q6EBC2; A2RUQ1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Interleukin-31;
DE Short=IL-31;
DE Flags: Precursor;
GN Name=IL31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Peripheral blood;
RX PubMed=15184896; DOI=10.1038/ni1084;
RA Dillon S.R., Sprecher C., Hammond A., Bilsborough J.,
RA Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B.,
RA Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P.,
RA Dong D.L., Dasovich M., Grant F.J., Lockwood L., Levin S.D., LeCiel C.,
RA Waggie K., Day H., Topouzis S., Kramer J., Kuestner R., Chen Z., Foster D.,
RA Parrish-Novak J., Gross J.A.;
RT "Interleukin 31, a cytokine produced by activated T cells, induces
RT dermatitis in mice.";
RL Nat. Immunol. 5:752-760(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INDUCTION.
RX PubMed=16461143; DOI=10.1016/j.jaci.2005.10.046;
RA Bilsborough J., Leung D.Y.M., Maurer M., Howell M., Boguniewicz M., Yao L.,
RA Storey H., LeCiel C., Harder B., Gross J.A.;
RT "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing
RT T cells in patients with atopic dermatitis.";
RL J. Allergy Clin. Immunol. 117:418-425(2006).
RN [4]
RP INDUCTION.
RX PubMed=17030248; DOI=10.1016/j.jaci.2006.07.015;
RA Neis M.M., Peters B., Dreuw A., Wenzel J., Bieber T., Mauch C., Krieg T.,
RA Stanzel S., Heinrich P.C., Merk H.F., Bosio A., Baron J.M., Hermanns H.M.;
RT "Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in
RT atopic and allergic contact dermatitis.";
RL J. Allergy Clin. Immunol. 118:930-937(2006).
CC -!- FUNCTION: Activates STAT3 and possibly STAT1 and STAT5 through the IL31
CC heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
CC May function in skin immunity (PubMed:15184896). Enhances myeloid
CC progenitor cell survival in vitro (By similarity). Induces RETNLA and
CC serum amyloid A protein expression in macrophages (By similarity).
CC {ECO:0000250|UniProtKB:Q6EAL8, ECO:0000269|PubMed:15184896}.
CC -!- INTERACTION:
CC Q6EBC2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-18286692, EBI-741158;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected at low levels in testis, bone marrow,
CC skeletal muscle, kidney, colon, thymus, small intestine and trachea.
CC {ECO:0000269|PubMed:15184896}.
CC -!- INDUCTION: Up-regulated in skin homing T-cells of patients with atopic
CC dermatitis (AD) and in activated circulating T-cells. Up-regulated in
CC lesional biopsies of patients with allergic contact dermatitis (ACD).
CC {ECO:0000269|PubMed:16461143, ECO:0000269|PubMed:17030248}.
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DR EMBL; AY499343; AAS86448.1; -; mRNA.
DR EMBL; BC132998; AAI32999.1; -; mRNA.
DR EMBL; BC133000; AAI33001.1; -; mRNA.
DR CCDS; CCDS31919.1; -.
DR RefSeq; NP_001014358.1; NM_001014336.1.
DR AlphaFoldDB; Q6EBC2; -.
DR BioGRID; 132118; 44.
DR IntAct; Q6EBC2; 1.
DR STRING; 9606.ENSP00000366234; -.
DR GlyGen; Q6EBC2; 2 sites.
DR BioMuta; IL31; -.
DR DMDM; 74709232; -.
DR MassIVE; Q6EBC2; -.
DR PaxDb; Q6EBC2; -.
DR PeptideAtlas; Q6EBC2; -.
DR PRIDE; Q6EBC2; -.
DR ProteomicsDB; 66275; -.
DR Antibodypedia; 19131; 437 antibodies from 37 providers.
DR DNASU; 386653; -.
DR Ensembl; ENST00000377035.2; ENSP00000366234.1; ENSG00000204671.2.
DR GeneID; 386653; -.
DR KEGG; hsa:386653; -.
DR MANE-Select; ENST00000377035.2; ENSP00000366234.1; NM_001014336.2; NP_001014358.1.
DR UCSC; uc001ubv.3; human.
DR CTD; 386653; -.
DR DisGeNET; 386653; -.
DR GeneCards; IL31; -.
DR HGNC; HGNC:19372; IL31.
DR HPA; ENSG00000204671; Not detected.
DR MIM; 609509; gene.
DR neXtProt; NX_Q6EBC2; -.
DR OpenTargets; ENSG00000204671; -.
DR PharmGKB; PA134957950; -.
DR VEuPathDB; HostDB:ENSG00000204671; -.
DR eggNOG; ENOG502TF53; Eukaryota.
DR GeneTree; ENSGT00390000018074; -.
DR HOGENOM; CLU_1660075_0_0_1; -.
DR InParanoid; Q6EBC2; -.
DR OMA; QHEPETE; -.
DR OrthoDB; 428855at2759; -.
DR PhylomeDB; Q6EBC2; -.
DR TreeFam; TF339844; -.
DR PathwayCommons; Q6EBC2; -.
DR Reactome; R-HSA-6788467; IL-6-type cytokine receptor ligand interactions.
DR SignaLink; Q6EBC2; -.
DR SIGNOR; Q6EBC2; -.
DR BioGRID-ORCS; 386653; 13 hits in 1059 CRISPR screens.
DR GeneWiki; Interleukin_31; -.
DR GenomeRNAi; 386653; -.
DR Pharos; Q6EBC2; Tbio.
DR PRO; PR:Q6EBC2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6EBC2; protein.
DR Bgee; ENSG00000204671; Expressed in mucosa of stomach and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005126; F:cytokine receptor binding; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR InterPro; IPR027987; IL-31.
DR PANTHER; PTHR38652; PTHR38652; 1.
DR Pfam; PF15209; IL31; 1.
PE 1: Evidence at protein level;
KW Cytokine; Glycoprotein; Immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..164
FT /note="Interleukin-31"
FT /id="PRO_0000274570"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 164 AA; 18205 MW; 1D61824CB6049445 CRC64;
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK MLLKDVEEEK
GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN KSVIDEIIEH LDKLIFQDAP
ETNISVPTDT HECKRFILTI SQQFSECMDL ALKSLTSGAQ QATT
