IL31_MOUSE
ID IL31_MOUSE Reviewed; 163 AA.
AC Q6EAL8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Interleukin-31;
DE Short=IL-31;
DE Flags: Precursor;
GN Name=Il31;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=BALB/cJ; TISSUE=Testis;
RX PubMed=15184896; DOI=10.1038/ni1084;
RA Dillon S.R., Sprecher C., Hammond A., Bilsborough J.,
RA Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B.,
RA Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P.,
RA Dong D.L., Dasovich M., Grant F.J., Lockwood L., Levin S.D., LeCiel C.,
RA Waggie K., Day H., Topouzis S., Kramer J., Kuestner R., Chen Z., Foster D.,
RA Parrish-Novak J., Gross J.A.;
RT "Interleukin 31, a cytokine produced by activated T cells, induces
RT dermatitis in mice.";
RL Nat. Immunol. 5:752-760(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=17379091; DOI=10.1016/j.exphem.2007.01.028;
RA Broxmeyer H.E., Li J., Hangoc G., Cooper S., Tao W., Mantel C.,
RA Graham-Evans B., Ghilardi N., de Sauvage F.J.;
RT "Regulation of myeloid progenitor cell proliferation/survival by IL-31
RT receptor and IL-31.";
RL Exp. Hematol. 35:78-86(2007).
RN [4]
RP FUNCTION.
RX PubMed=25847241; DOI=10.1074/jbc.m114.622126;
RA Edukulla R., Singh B., Jegga A.G., Sontake V., Dillon S.R., Madala S.K.;
RT "Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-
RT 31RA Expression.";
RL J. Biol. Chem. 290:13510-13520(2015).
CC -!- FUNCTION: Activates STAT3 and possibly STAT1 and STAT5 through the IL31
CC heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
CC May function in skin immunity (PubMed:15184896). Enhances myeloid
CC progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and
CC serum amyloid A protein expression in macrophages (PubMed:25847241).
CC {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:17379091,
CC ECO:0000269|PubMed:25847241}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- MISCELLANEOUS: Il31 transgenic mice develop dermatitis. A similar
CC phenotype is caused by local delivery of Il31.
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DR EMBL; AY509149; AAS82846.1; -; mRNA.
DR EMBL; BC117082; AAI17083.1; -; mRNA.
DR EMBL; BC117084; AAI17085.1; -; mRNA.
DR CCDS; CCDS51645.1; -.
DR RefSeq; NP_083870.1; NM_029594.1.
DR RefSeq; XP_006530561.1; XM_006530498.1.
DR AlphaFoldDB; Q6EAL8; -.
DR SMR; Q6EAL8; -.
DR STRING; 10090.ENSMUSP00000031389; -.
DR GlyGen; Q6EAL8; 3 sites.
DR PaxDb; Q6EAL8; -.
DR PRIDE; Q6EAL8; -.
DR Antibodypedia; 19131; 437 antibodies from 37 providers.
DR Ensembl; ENSMUST00000031389; ENSMUSP00000031389; ENSMUSG00000029437.
DR GeneID; 76399; -.
DR KEGG; mmu:76399; -.
DR UCSC; uc008zns.2; mouse.
DR CTD; 386653; -.
DR MGI; MGI:1923649; Il31.
DR VEuPathDB; HostDB:ENSMUSG00000029437; -.
DR eggNOG; ENOG502TF53; Eukaryota.
DR GeneTree; ENSGT00390000018074; -.
DR HOGENOM; CLU_1424604_0_0_1; -.
DR InParanoid; Q6EAL8; -.
DR OMA; QHEPETE; -.
DR OrthoDB; 1401355at2759; -.
DR PhylomeDB; Q6EAL8; -.
DR TreeFam; TF339844; -.
DR Reactome; R-MMU-6788467; IL-6-type cytokine receptor ligand interactions.
DR BioGRID-ORCS; 76399; 1 hit in 69 CRISPR screens.
DR PRO; PR:Q6EAL8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6EAL8; protein.
DR Bgee; ENSMUSG00000029437; Expressed in spermatid and 19 other tissues.
DR ExpressionAtlas; Q6EAL8; baseline and differential.
DR Genevisible; Q6EAL8; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0005126; F:cytokine receptor binding; IPI:MGI.
DR GO; GO:0005147; F:oncostatin-M receptor binding; IMP:MGI.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR InterPro; IPR027987; IL-31.
DR PANTHER; PTHR38652; PTHR38652; 1.
DR Pfam; PF15209; IL31; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Glycoprotein; Immunity; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..163
FT /note="Interleukin-31"
FT /id="PRO_0000274571"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 163 AA; 18120 MW; B10487274DF8DFF4 CRC64;
MIFHTGTTKP TLVLLCCIGT WLATCSLSFG APISKEDLRT TIDLLKQESQ DLYNNYSIKQ
ASGMSADESI QLPCFSLDRE ALTNISVIIA HLEKVKVLSE NTVDTSWVIR WLTNISCFNP
LNLNISVPGN TDESYDCKVF VLTVLKQFSN CMAELQAKDN TTC
