ID   IL34_RAT                Reviewed;         234 AA.
AC   Q4KM46;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Interleukin-34;
DE            Short=IL-34;
DE   Flags: Precursor;
GN   Name=Il34;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytokine that promotes the proliferation, survival and
CC       differentiation of monocytes and macrophages. Promotes the release of
CC       pro-inflammatory chemokines, and thereby plays an important role in
CC       innate immunity and in inflammatory processes. Plays an important role
CC       in the regulation of osteoclast proliferation and differentiation, and
CC       in the regulation of bone resorption. Signaling via CSF1R and its
CC       downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND
CC       MAPK3/ERK1 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with CSF1R (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-34 family. {ECO:0000305}.
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DR   EMBL; BC098808; AAH98808.1; -; mRNA.
DR   RefSeq; NP_001020937.1; NM_001025766.1.
DR   RefSeq; XP_006255662.1; XM_006255600.3.
DR   AlphaFoldDB; Q4KM46; -.
DR   SMR; Q4KM46; -.
DR   STRING; 10116.ENSRNOP00000023823; -.
DR   GlyGen; Q4KM46; 1 site.
DR   PaxDb; Q4KM46; -.
DR   GeneID; 498951; -.
DR   KEGG; rno:498951; -.
DR   UCSC; RGD:1586038; rat.
DR   CTD; 146433; -.
DR   RGD; 1586038; Il34.
DR   eggNOG; ENOG502S2ET; Eukaryota.
DR   HOGENOM; CLU_102223_1_0_1; -.
DR   InParanoid; Q4KM46; -.
DR   PhylomeDB; Q4KM46; -.
DR   Reactome; R-RNO-449836; Other interleukin signaling.
DR   PRO; PR:Q4KM46; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q4KM46; RN.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005157; F:macrophage colony-stimulating factor receptor binding; ISS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0061514; P:interleukin-34-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0061518; P:microglial cell proliferation; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0010759; P:positive regulation of macrophage chemotaxis; ISO:RGD.
DR   GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:RGD.
DR   GO; GO:0120041; P:positive regulation of macrophage proliferation; ISO:RGD.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:RGD.
DR   GO; GO:0045657; P:positive regulation of monocyte differentiation; ISO:RGD.
DR   GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; ISO:RGD.
DR   Gene3D; 1.20.1250.80; -; 1.
DR   InterPro; IPR020415; IL-34.
DR   InterPro; IPR038328; IL-34_sf.
DR   PANTHER; PTHR28606; PTHR28606; 1.
DR   Pfam; PF15036; IL34; 1.
DR   PRINTS; PR01938; INTRLEUKIN34.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Growth factor; Immunity; Inflammatory response;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..234
FT                   /note="Interleukin-34"
FT                   /id="PRO_0000294350"
FT   REGION          215..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   234 AA;  26772 MW;  3AC004AEEFFB5608 CRC64;
     MPWGLAWLYC LGILLDVALG NENLEIWTLA QDKECDLTGY LRGKLQYKNR LQYMKHYFPI
     NYRIAVPYEG VLRVANITRL KAHVSERELR YLWVLVSLNA TESVLDVLLE GHPSWKYLQE
     VQTLLENVQR SLMDVEIGPH VEAVLSLLST PGLSLKLVRP KALLDNCFRV MELLYCSCCK
     QSPILKWQDC ELPRLHPHSP ESLMQCAATN VYPLPRQPPT SLPRSPSSNH GPLP