IL36G_MOUSE
ID IL36G_MOUSE Reviewed; 164 AA.
AC Q8R460; Q14BB6;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Interleukin-36 gamma;
DE AltName: Full=Interleukin-1 family member 9;
DE Short=IL-1F9;
DE Flags: Precursor;
GN Name=Il36g {ECO:0000312|MGI:MGI:2449929};
GN Synonyms=Il1f9 {ECO:0000312|MGI:MGI:2449929};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RX PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT "Genomic organization of the interleukin-1 locus.";
RL Genomics 79:726-733(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=21860022; DOI=10.1182/blood-2011-05-356873;
RA Vigne S., Palmer G., Lamacchia C., Martin P., Talabot-Ayer D.,
RA Rodriguez E., Ronchi F., Sallusto F., Dinh H., Sims J.E., Gabay C.;
RT "IL-36R ligands are potent regulators of dendritic and T cells.";
RL Blood 118:5813-5823(2011).
RN [4]
RP FUNCTION, AND PROCESSING.
RX PubMed=21965679; DOI=10.1074/jbc.m111.267922;
RA Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A.,
RA Sims J.E.;
RT "Interleukin-36 (IL-36) ligands require processing for full agonist (IL-
RT 36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity.";
RL J. Biol. Chem. 286:42594-42602(2011).
CC -!- FUNCTION: Functions as an agonist of NF-kappa B activation through the
CC orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36
CC signaling system that is thought to be present in epithelial barriers
CC and to take part in local inflammatory response; similar to the IL-1
CC system with which it shares the coreceptor IL1RAP (By similarity).
CC Seems to be involved in skin inflammatory response by acting on
CC keratinocytes, dendritic cells and indirectly on T-cells to drive
CC tissue infiltration, cell maturation and cell proliferation. May play a
CC role in pro-inflammatory responses during particular neutrophilic
CC airway inflammation. May be involved in the innate immune response to
CC fungal pathogens. Induces the production of pro-inflammatory cytokines
CC in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1
CC beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation
CC by stimulating the surface expression of CD80, CD86 and MHC class II.
CC Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+)
CC T-cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH8,
CC ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
CC -!- SUBUNIT: Interacts with cargo receptor TMED10; the interaction mediates
CC the translocation from the cytoplasm into the ERGIC (endoplasmic
CC reticulum-Golgi intermediate compartment) and thereby secretion.
CC {ECO:0000250|UniProtKB:Q9NZH8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZH8}.
CC Secreted {ECO:0000250|UniProtKB:Q9NZH8}. Note=The secretion is
CC dependent on protein unfolding and facilitated by the cargo receptor
CC TMED10; it results in protein translocation from the cytoplasm into the
CC ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed
CC by vesicle entry and secretion. {ECO:0000250|UniProtKB:Q9NZH8}.
CC -!- PTM: N-terminal truncation leads to a dramatic enhancement of its
CC activity (>1000-fold) (PubMed:21965679). Proteolytically cleaved by
CC cathepsin CTSG (By similarity). {ECO:0000250|UniProtKB:Q9NZH8,
CC ECO:0000269|PubMed:21965679}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR EMBL; AY071843; AAL67153.1; -; mRNA.
DR EMBL; BC116227; AAI16228.1; -; mRNA.
DR EMBL; BC116228; AAI16229.1; -; mRNA.
DR AlphaFoldDB; Q8R460; -.
DR SMR; Q8R460; -.
DR STRING; 10090.ENSMUSP00000053391; -.
DR MaxQB; Q8R460; -.
DR PaxDb; Q8R460; -.
DR PRIDE; Q8R460; -.
DR MGI; MGI:2449929; Il36g.
DR eggNOG; ENOG502STX9; Eukaryota.
DR InParanoid; Q8R460; -.
DR Reactome; R-MMU-9014826; Interleukin-36 pathway.
DR PRO; PR:Q8R460; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R460; protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IGI:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:MGI.
DR GO; GO:1901740; P:negative regulation of myoblast fusion; IMP:MGI.
DR GO; GO:0001819; P:positive regulation of cytokine production; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IGI:MGI.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078; PTHR10078; 1.
DR Pfam; PF00340; IL1; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW Reference proteome; Secreted.
FT PROPEP 1..12
FT /evidence="ECO:0000269|PubMed:21965679"
FT /id="PRO_0000430550"
FT CHAIN 13..164
FT /note="Interleukin-36 gamma"
FT /id="PRO_0000153649"
SQ SEQUENCE 164 AA; 18733 MW; A7338D475DFEADBE CRC64;
MFSKHPFSTH ISGRETPDFG EVFDLDQQVW IFRNQALVTV PRSHRVTPVS VTILPCKYPE
SLEQDKGIAI YLGIQNPDKC LFCKEVNGHP TLLLKEEKIL DLYHHPEPMK PFLFYHTRTG
GTSTFESVAF PGHYIASSKT GNPIFLTSKK GEYYNINFNL DIKS
