IL3_BOVIN
ID IL3_BOVIN Reviewed; 144 AA.
AC P49875;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Interleukin-3;
DE Short=IL-3;
DE AltName: Full=Hematopoietic growth factor;
DE AltName: Full=Mast cell growth factor;
DE Short=MCGF;
DE AltName: Full=Multipotential colony-stimulating factor;
DE AltName: Full=P-cell-stimulating factor;
DE Flags: Precursor;
GN Name=IL3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RX PubMed=7557449; DOI=10.1016/0378-1119(95)00359-e;
RA Mwangi S.M., Logan-Henfrey L., McInnes C., Mertens B.;
RT "Cloning of the bovine interleukin-3-encoding cDNA.";
RL Gene 162:309-312(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
RC STRAIN=N'Dama;
RA Mwangi S.M.;
RL Thesis (1996), International Livestock Research Institute, Kenya.
CC -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC cytokines that act in hematopoiesis by controlling the production,
CC differentiation, and function of 2 related white cell populations of
CC the blood, the granulocytes and the monocytes-macrophages.
CC {ECO:0000250}.
CC -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC cells, erythroid cells, eosinophils and megakaryocytes. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR EMBL; L31893; AAA99502.1; -; mRNA.
DR EMBL; U72065; AAB17188.1; -; Genomic_DNA.
DR PIR; JC4266; JC4266.
DR RefSeq; NP_776345.1; NM_173920.2.
DR AlphaFoldDB; P49875; -.
DR SMR; P49875; -.
DR STRING; 9913.ENSBTAP00000002774; -.
DR PaxDb; P49875; -.
DR PRIDE; P49875; -.
DR Ensembl; ENSBTAT00000002774; ENSBTAP00000002774; ENSBTAG00000002140.
DR GeneID; 280823; -.
DR KEGG; bta:280823; -.
DR CTD; 3562; -.
DR VEuPathDB; HostDB:ENSBTAG00000002140; -.
DR eggNOG; ENOG502TD4X; Eukaryota.
DR GeneTree; ENSGT00940000163393; -.
DR HOGENOM; CLU_144877_0_0_1; -.
DR InParanoid; P49875; -.
DR OMA; IKDGDWN; -.
DR OrthoDB; 1415445at2759; -.
DR TreeFam; TF338567; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000002140; Expressed in abdominal lymph node and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002183; IL-3.
DR Pfam; PF02059; IL3; 1.
DR PIRSF; PIRSF001939; IL-3; 1.
DR PRINTS; PR00430; INTERLEUKIN3.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..144
FT /note="Interleukin-3"
FT /id="PRO_0000015513"
SQ SEQUENCE 144 AA; 16380 MW; 57CD0E826BCD0F26 CRC64;
MSSLSILHLL LLLLALHAPQ AKGLPVVTSR TPYSMLMKEI MDDLKKITPS PEGSLNSDEK
NFLTKESLLQ ANLKVFMTFA TDTFGSDSKI MKNLKEFQPV LPTATPTEDP IFIENKNLGD
FRMKLEEYLV IIRNYLKSKN IWFS
