ID   IL3_CALJA               Reviewed;         142 AA.
AC   Q28334;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3;
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8110834; DOI=10.1016/0167-4781(94)90034-5;
RA   Burger H., Mostert M.C., Kok E.M., Wagemaker G., Dorssers L.C.J.;
RT   "Cloning and expression of interleukin-3 genes of chimpanzee and New World
RT   monkeys.";
RL   Biochim. Biophys. Acta 1217:195-198(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7932787; DOI=10.1007/bf00160149;
RA   Burger H., Wagemaker G., Leunissen J.A.M., Dorssers L.C.J.;
RT   "Molecular evolution of interleukin-3.";
RL   J. Mol. Evol. 39:255-267(1994).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC       {ECO:0000250}.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
CC       cells.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; X74877; CAA52864.1; -; mRNA.
DR   PIR; S42721; S42721.
DR   RefSeq; XP_002744658.1; XM_002744612.2.
DR   AlphaFoldDB; Q28334; -.
DR   SMR; Q28334; -.
DR   STRING; 9483.ENSCJAP00000023670; -.
DR   Ensembl; ENSCJAT00000025040; ENSCJAP00000023670; ENSCJAG00000012921.
DR   KEGG; cjc:100410529; -.
DR   eggNOG; ENOG502TD4X; Eukaryota.
DR   GeneTree; ENSGT00940000163393; -.
DR   HOGENOM; CLU_144877_0_0_1; -.
DR   InParanoid; Q28334; -.
DR   OMA; IKDGDWN; -.
DR   OrthoDB; 1415445at2759; -.
DR   TreeFam; TF338567; -.
DR   Proteomes; UP000008225; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..142
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015514"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        34..102
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  15980 MW;  DC27E4F0AF3D2366 CRC64;
     MSHLPILLLL LLVSPGLQAA PTQTMPLKTT QVNCSNLREE IVTLLNQPPL ASSNFNNLNR
     EDQRILMKPN LRKPNLEAFQ KAVKSLQNAA AIESNLKDLP VCLPTATNAA TQHPIRIKDG
     DWNDFQMKLK FYLKTLEIKQ PQ