ID   IL3_CANLF               Reviewed;         143 AA.
AC   Q9BDX4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   McSweeney P.A., Gass M.J., Brunvand M.W., Lioubin M.N., Nash R.A.;
RT   "The cloning and expression of the gene for canine interleukin-3.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC       {ECO:0000250}.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; AF250764; AAK37958.1; -; Genomic_DNA.
DR   RefSeq; NP_001013857.1; NM_001013835.1.
DR   RefSeq; XP_013973137.1; XM_014117662.1.
DR   AlphaFoldDB; Q9BDX4; -.
DR   SMR; Q9BDX4; -.
DR   STRING; 9612.ENSCAFP00000001172; -.
DR   PaxDb; Q9BDX4; -.
DR   Ensembl; ENSCAFT00030023305; ENSCAFP00030020320; ENSCAFG00030012590.
DR   Ensembl; ENSCAFT00040029585; ENSCAFP00040025703; ENSCAFG00040016064.
DR   GeneID; 481497; -.
DR   KEGG; cfa:481497; -.
DR   CTD; 3562; -.
DR   eggNOG; ENOG502TD4X; Eukaryota.
DR   HOGENOM; CLU_144877_0_0_1; -.
DR   InParanoid; Q9BDX4; -.
DR   OMA; IKDGDWN; -.
DR   OrthoDB; 1415445at2759; -.
DR   TreeFam; TF338567; -.
DR   Proteomes; UP000002254; Unplaced.
DR   Bgee; ENSCAFG00000000817; Expressed in occipital cortex and 1 other tissue.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   3: Inferred from homology;
KW   Cytokine; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..143
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015515"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  16499 MW;  2126D96465887324 CRC64;
     MSSFPILHLL LLLLGCQVPQ AQGRPFSTDL PKQYFTMINE IMEMLNKSPS PSEEPLDSNE
     KETLLEDTLL RPNLDVFLNA SSKFHKNGLL IWNNLKEFLP LLPTPTPRGE PISIMENNWG
     DFQRKLKKYL EALDNFLNFK NKP