ID   IL3_HYLLA               Reviewed;         152 AA.
AC   P06740;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3;
OS   Hylobates lar (Common gibbon) (White-handed gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3489530; DOI=10.1016/0092-8674(86)90360-0;
RA   Yang Y.-C., Ciarletta A.B., Temple P.A., Chung M.P., Kovacic S.,
RA   Witek-Giannotti J.S., Leary A.C., Kriz R., Donahue R.E., Wong G.G.,
RA   Clark S.C.;
RT   "Human IL-3 (multi-CSF): identification by expression cloning of a novel
RT   hematopoietic growth factor related to murine IL-3.";
RL   Cell 47:3-10(1986).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
CC       cells.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; M14744; AAA35455.1; -; mRNA.
DR   AlphaFoldDB; P06740; -.
DR   SMR; P06740; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..152
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015517"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..103
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   152 AA;  17207 MW;  F63438A0D2577B3A CRC64;
     MSCLPVLLLL QLLVSPGLQA PMTQTTSLKT SWVNCSNMID EIITHLKQPP LPLLDFNNLN
     GEDQDILMEN NLRRPNLEAF NKAVKSLQNA SAIESILKNL PPCLPMATAA PTRHPIRIKD
     GDWNEFRRKL KFYLKTLENE QAQQMTLSLE IS