ID   IL3_MACMU               Reviewed;         143 AA.
AC   P25140;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2251147; DOI=10.1093/nar/18.22.6718;
RA   Burger H., Dorssers L.C.J., van Leen R.W., Wagemaker G.;
RT   "Nucleotide sequence of the gene encoding rhesus monkey (Macaca mulatta)
RT   interleukin-3.";
RL   Nucleic Acids Res. 18:6718-6718(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2257297;
RA   Burger H., van Leen R.W., Dorssers L.C.J., Persoon N.L.M., Lemson P.J.,
RA   Wagemaker G.;
RT   "Species specificity of human interleukin-3 demonstrated by cloning and
RT   expression of the homologous rhesus monkey (Macaca mulatta) gene.";
RL   Blood 76:2229-2234(1990).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
CC       cells.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; X51890; CAA36172.1; -; Genomic_DNA.
DR   PIR; A60159; A60159.
DR   RefSeq; NP_001095204.1; NM_001101734.1.
DR   AlphaFoldDB; P25140; -.
DR   SMR; P25140; -.
DR   STRING; 9544.ENSMMUP00000022233; -.
DR   Ensembl; ENSMMUT00000023756; ENSMMUP00000022233; ENSMMUG00000016912.
DR   GeneID; 706946; -.
DR   KEGG; mcc:706946; -.
DR   CTD; 3562; -.
DR   VEuPathDB; HostDB:ENSMMUG00000016912; -.
DR   VGNC; VGNC:84395; IL3.
DR   eggNOG; ENOG502TD4X; Eukaryota.
DR   GeneTree; ENSGT00940000163393; -.
DR   HOGENOM; CLU_144877_0_0_1; -.
DR   InParanoid; P25140; -.
DR   OMA; IKDGDWN; -.
DR   OrthoDB; 1415445at2759; -.
DR   TreeFam; TF338567; -.
DR   Proteomes; UP000006718; Chromosome 6.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..143
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015518"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        35..103
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   143 AA;  16087 MW;  1F1FBFC26F9A0C25 CRC64;
     MSRLPVLLLL HLLVSPGLQA PMTQTTSLKT SWAKCSNMID EIITHLNQPP LPSPDFNNLN
     EEDQTILVEK NLRRSNLEAF SKAVKSLQNA SAIESILKNL PPCLPMATAA PTRPPIRITN
     GDRNDFRRKL KFYLKTLENE QAQ