ID   IL3_SAGOE               Reviewed;         142 AA.
AC   P51445;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3;
OS   Saguinus oedipus (Cotton-top tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Saguinus.
OX   NCBI_TaxID=9490;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8110834; DOI=10.1016/0167-4781(94)90034-5;
RA   Burger H., Mostert M.C., Kok E.M., Wagemaker G., Dorssers L.C.J.;
RT   "Cloning and expression of interleukin-3 genes of chimpanzee and New World
RT   monkeys.";
RL   Biochim. Biophys. Acta 1217:195-198(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7932787; DOI=10.1007/bf00160149;
RA   Burger H., Wagemaker G., Leunissen J.A.M., Dorssers L.C.J.;
RT   "Molecular evolution of interleukin-3.";
RL   J. Mol. Evol. 39:255-267(1994).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
CC       cells.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; X74878; CAA52865.1; -; Genomic_DNA.
DR   EMBL; X74879; CAA52865.1; JOINED; Genomic_DNA.
DR   PIR; S42722; S42722.
DR   AlphaFoldDB; P51445; -.
DR   SMR; P51445; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..142
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015522"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        34..102
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  16085 MW;  EF23BBEA67DFFFC0 CRC64;
     MSHLPILLLL LLVSPGLQAA PTQTTSLKAT QVNCSNLREE IVTLLNQPPL PSSNFNNLNR
     EDQRILMKPN LRRPNLEAFQ KAVKSLQNAT AIESSLKDLP LCLPMATNAS MQHPIRIKDG
     DWNDFRMKLK FYLKTLEIKQ PQ