ID   IL3_SHEEP               Reviewed;         146 AA.
AC   Q06435;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Interleukin-3;
DE            Short=IL-3;
DE   AltName: Full=Hematopoietic growth factor;
DE   AltName: Full=Mast cell growth factor;
DE            Short=MCGF;
DE   AltName: Full=Multipotential colony-stimulating factor;
DE   AltName: Full=P-cell-stimulating factor;
DE   Flags: Precursor;
GN   Name=IL3; Synonyms=IL-3;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Suffolk;
RX   PubMed=8405235;
RA   McInnes C.J., Haig D., Logan M.;
RT   "The cloning and expression of the gene for ovine interleukin-3 (multi-CSF)
RT   and a comparison of the in vitro hematopoietic activity of ovine IL-3 with
RT   ovine GM-CSF and human M-CSF.";
RL   Exp. Hematol. 21:1528-1534(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8112621; DOI=10.1016/0378-1119(94)90772-2;
RA   McInnes C.J., Logan M., Haig D., Wright F.;
RT   "Cloning of a cDNA encoding ovine interleukin-3.";
RL   Gene 139:289-290(1994).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages.
CC   -!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells, stem
CC       cells, erythroid cells, eosinophils and megakaryocytes.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
CC       cells.
CC   -!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
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DR   EMBL; Z18897; CAA79334.1; -; Genomic_DNA.
DR   EMBL; Z18291; CAA79162.1; -; mRNA.
DR   PIR; I46407; I46407.
DR   RefSeq; NP_001009420.1; NM_001009420.2.
DR   AlphaFoldDB; Q06435; -.
DR   SMR; Q06435; -.
DR   STRING; 9940.ENSOARP00000016653; -.
DR   Ensembl; ENSOART00020000760; ENSOARP00020000603; ENSOARG00020000584.
DR   GeneID; 443438; -.
DR   KEGG; oas:443438; -.
DR   CTD; 3562; -.
DR   eggNOG; ENOG502TD4X; Eukaryota.
DR   OrthoDB; 1415445at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005135; F:interleukin-3 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002183; IL-3.
DR   Pfam; PF02059; IL3; 1.
DR   PIRSF; PIRSF001939; IL-3; 1.
DR   PRINTS; PR00430; INTERLEUKIN3.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..146
FT                   /note="Interleukin-3"
FT                   /id="PRO_0000015523"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  16233 MW;  F8ACFEB9A7D2F6D0 CRC64;
     MSSLSILHLL LLLLSLHAPQ AQGLPLRTPR TPYSSLMEEI MDDLKKITPS PEGSLNSDEK
     NILANKSLLQ ANLKAFMTFA TDTFGSDSKI MKNLKEFQPV LPTATPTEDS ILIEDSNLGD
     FRMKLEEYLA TIRGYLRHDL AAAETI