IL40_MOUSE
ID IL40_MOUSE Reviewed; 252 AA.
AC Q9CX63; B1ATC1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein IL-40 {ECO:0000305};
DE AltName: Full=Interleukin-40 {ECO:0000303|PubMed:28978694};
DE Short=IL-40 {ECO:0000303|PubMed:28978694};
DE Flags: Precursor;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=28978694; DOI=10.4049/jimmunol.1700534;
RA Catalan-Dibene J., Vazquez M.I., Luu V.P., Nuccio S.P., Karimzadeh A.,
RA Kastenschmidt J.M., Villalta S.A., Ushach I., Pone E.J., Casali P.,
RA Raffatellu M., Burkhardt A.M., Hernandez-Ruiz M., Heller G., Hevezi P.A.,
RA Zlotnik A.;
RT "Identification of IL-40, a novel B cell-associated cytokine.";
RL J. Immunol. 199:3326-3335(2017).
CC -!- FUNCTION: Probable B cell-associated cytokine that plays a role in the
CC regulation of humoral immune responses (PubMed:28978694). Involved in
CC lymphocyte B cell development and immunoglobulin/IgA production
CC (PubMed:28978694). {ECO:0000269|PubMed:28978694}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX52}.
CC -!- TISSUE SPECIFICITY: Expressed in bone marrow, spleen and lymph node
CC (PubMed:28978694). {ECO:0000269|PubMed:28978694}.
CC -!- INDUCTION: Up-regulated in the mammary gland upon the onset of
CC lactation (PubMed:28978694). Up-regulated in peripheral blood
CC lymphocyte B cells upon activation (PubMed:28978694).
CC {ECO:0000269|PubMed:28978694}.
CC -!- DISRUPTION PHENOTYPE: Mice are viable and reproduce normally
CC (PubMed:28978694). Show reduced number of both peripheral lymphocyte B
CC cells in the spleen and precursor and mature lymphocyte B cells in the
CC bone marrow (PubMed:28978694). Show smaller and fewer Peyer's patches,
CC lower numbers of immunoglobulin/IgA-secreting B cells and an altered
CC gut microbiome (PubMed:28978694). Exhibit reduced levels of
CC immunoglobulin/IgA in the serum, gut, feces, and lactating mammary
CC gland (PubMed:28978694). {ECO:0000269|PubMed:28978694}.
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DR EMBL; AK020081; BAB31985.1; -; mRNA.
DR EMBL; AL645856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48992.1; -.
DR RefSeq; NP_084240.1; NM_029964.1.
DR AlphaFoldDB; Q9CX63; -.
DR GlyGen; Q9CX63; 2 sites.
DR iPTMnet; Q9CX63; -.
DR PhosphoSitePlus; Q9CX63; -.
DR PaxDb; Q9CX63; -.
DR PRIDE; Q9CX63; -.
DR Antibodypedia; 32542; 22 antibodies from 11 providers.
DR Ensembl; ENSMUST00000106331; ENSMUSP00000101938; ENSMUSG00000025573.
DR GeneID; 77727; -.
DR KEGG; mmu:77727; -.
DR UCSC; uc007mnv.2; mouse.
DR MGI; MGI:1924977; 6030468B19Rik.
DR VEuPathDB; HostDB:ENSMUSG00000025573; -.
DR eggNOG; ENOG502SPUE; Eukaryota.
DR GeneTree; ENSGT01050000244988; -.
DR HOGENOM; CLU_096525_0_0_1; -.
DR InParanoid; Q9CX63; -.
DR OMA; NSVNVQH; -.
DR OrthoDB; 1252265at2759; -.
DR PhylomeDB; Q9CX63; -.
DR TreeFam; TF337680; -.
DR BioGRID-ORCS; 77727; 2 hits in 75 CRISPR screens.
DR PRO; PR:Q9CX63; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CX63; protein.
DR Bgee; ENSMUSG00000025573; Expressed in yolk sac and 19 other tissues.
DR Genevisible; Q9CX63; MM.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0002313; P:mature B cell differentiation involved in immune response; IMP:UniProtKB.
DR GO; GO:2000558; P:positive regulation of immunoglobulin production in mucosal tissue; IMP:UniProtKB.
DR GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040878; Ig_C17orf99.
DR Pfam; PF17736; Ig_C17orf99; 2.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cytokine; Glycoprotein; Immunity; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..252
FT /note="Protein IL-40"
FT /id="PRO_0000272655"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 252 AA; 26851 MW; 3F5F6339341F206B CRC64;
MALLQLLLFA MLAACGFSEE QTEGITIAYK VLEVYPQSRR VLITCDAPEA SQPITYSLLA
SRGILVAKKV VHDSVPASFN INITIKSSPD LLTYSCQATS NSGTYGPSSR LQMYQELWAK
PVSQLQADFV LRHGDSGPTV ELSCLASSGS PPITYRLVGN GGRVLAQQRP LHGKPANFSL
PLSQTTGWFQ CEAENDVGVD SSARIPLPRA EARAKLVTTL AGELPLTPTC ILAGSLVSIA
VIASRMLSST GL
