ID   IL4_AILME               Reviewed;         132 AA.
AC   Q3S4V6; Q0MS73;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Interleukin-4;
DE            Short=IL-4;
DE   AltName: Full=B-cell stimulatory factor 1;
DE            Short=BSF-1;
DE   AltName: Full=Lymphocyte stimulatory factor 1;
DE   Flags: Precursor;
GN   Name=IL4;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wu Z., Xu L., Zhang S., Zou F., Yue B., Zhang Z., Zeng B.;
RT   "Molecular cloning and expression of interleukin 4 from giant panda.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang D., Yang G., Zhang Z., Zhang A., Guo W., Hou R., Wang C., Shen F.;
RT   "Cloning and sequence analysis of IL-4 gene in Ailuropoda melanoleuca.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in at least several B-cell activation processes
CC       as well as of other cell types. It is a costimulator of DNA-synthesis.
CC       It induces the expression of class II MHC molecules on resting B-cells.
CC       It enhances both secretion and cell surface expression of IgE and IgG1.
CC       It also regulates the expression of the low affinity Fc receptor for
CC       IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC       IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC       cells by interfering with mTORC1 signaling and through the induction of
CC       RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR   EMBL; DQ166512; AAZ94160.1; -; mRNA.
DR   EMBL; DQ852340; ABH10825.1; -; mRNA.
DR   RefSeq; NP_001291840.1; NM_001304911.1.
DR   AlphaFoldDB; Q3S4V6; -.
DR   SMR; Q3S4V6; -.
DR   Ensembl; ENSAMET00000019474; ENSAMEP00000018724; ENSAMEG00000017724.
DR   GeneID; 100482473; -.
DR   KEGG; aml:100482473; -.
DR   CTD; 3565; -.
DR   GeneTree; ENSGT00390000013108; -.
DR   InParanoid; Q3S4V6; -.
DR   OrthoDB; 1495672at2759; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002354; IL-4.
DR   InterPro; IPR001325; IL-4/IL-13.
DR   InterPro; IPR018096; IL-4/IL-13_CS.
DR   PANTHER; PTHR47401; PTHR47401; 1.
DR   Pfam; PF00727; IL4; 1.
DR   PIRSF; PIRSF001941; Interleukin_4; 1.
DR   PRINTS; PR00431; INTERLEUKIN4.
DR   SMART; SM00190; IL4_13; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..132
FT                   /note="Interleukin-4"
FT                   /id="PRO_0000042904"
FT   CARBOHYD        28
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        48..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        70..104
FT                   /evidence="ECO:0000250"
FT   CONFLICT        2
FT                   /note="G -> C (in Ref. 2; ABH10825)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   132 AA;  14885 MW;  A4BE3B7C5B7EF2D7 CRC64;
     MGLTSQLIPT LVCLLALTST FVHGHNFNIT IKEIIKTLNI LTARNDTCME LTVTNIFAAP
     KNTTDTETFC RATTVLQQLS THSCSNKLLG GLHRNLKTMA NMTCSVNEVK KSTLRDFLER
     LKAIVQRKYY RH