IL4_BOVIN
ID IL4_BOVIN Reviewed; 135 AA.
AC P30367; A9QWQ7;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1601309; DOI=10.1016/0378-1119(92)90587-f;
RA Heussler V.T., Eichhorn M., Dobbelaere D.A.;
RT "Cloning of a full-length cDNA encoding bovine interleukin 4 by the
RT polymerase chain reaction.";
RL Gene 114:273-278(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7626886; DOI=10.1007/bf00364799;
RA Buitkamp J., Schwaiger F.W., Solinas-Toldo S., Fries R., Epplen J.T.;
RT "The bovine interleukin-4 gene: genomic organization, localization, and
RT evolution.";
RL Mamm. Genome 6:350-356(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG U.S. Veterinary Immune Reagent Network;
RA Hudgens T., Tompkins D., Baldwin C.L.;
RT "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; M77120; AAA30587.1; -; mRNA.
DR EMBL; U14160; AAA82730.1; -; Genomic_DNA.
DR EMBL; U14131; AAA82730.1; JOINED; Genomic_DNA.
DR EMBL; U14159; AAA82730.1; JOINED; Genomic_DNA.
DR EMBL; EU276069; ABX72067.1; -; mRNA.
DR PIR; JH0684; JH0684.
DR RefSeq; NP_776346.1; NM_173921.2.
DR AlphaFoldDB; P30367; -.
DR SMR; P30367; -.
DR STRING; 9913.ENSBTAP00000021215; -.
DR PaxDb; P30367; -.
DR PRIDE; P30367; -.
DR Ensembl; ENSBTAT00000021215; ENSBTAP00000021215; ENSBTAG00000015957.
DR GeneID; 280824; -.
DR KEGG; bta:280824; -.
DR CTD; 3565; -.
DR VEuPathDB; HostDB:ENSBTAG00000015957; -.
DR VGNC; VGNC:30161; IL4.
DR eggNOG; KOG3886; Eukaryota.
DR GeneTree; ENSGT00390000013108; -.
DR HOGENOM; CLU_154691_0_0_1; -.
DR InParanoid; P30367; -.
DR OMA; SCMELTV; -.
DR OrthoDB; 1495672at2759; -.
DR TreeFam; TF336383; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000015957; Expressed in mesenteric lymph node and 22 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IBA:GO_Central.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IBA:GO_Central.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IBA:GO_Central.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IBA:GO_Central.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IBA:GO_Central.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IBA:GO_Central.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
DR GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..135
FT /note="Interleukin-4"
FT /id="PRO_0000015524"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..135
FT /evidence="ECO:0000250"
FT DISULFID 48..85
FT /evidence="ECO:0000250"
FT DISULFID 70..105
FT /evidence="ECO:0000250"
FT CONFLICT 5
FT /note="S -> Y (in Ref. 1; AAA30587)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 15119 MW; ECF0B18B88B4271C CRC64;
MGLTSQLIPV LVCLLVCTSH FVHGHKCDIT LAEIIKTLNI LTTRKNSCME LPVADVFAAP
KNTTEKETFC RVGIELRRIY RSHTCLNKFL GGLDRNLNSL ASKTCSVNEA KTSTSTLKDL
LERLKTIMKE KYSKC
