IL4_BUBBU
ID IL4_BUBBU Reviewed; 135 AA.
AC Q7YS71;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Bubalus bubalis (Domestic water buffalo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bubalus.
OX NCBI_TaxID=89462;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RA Hatle K.M., Saini M., Sharma B., Joshi P., Gupta P.K.;
RT "Molecular cloning and characterization of the cDNA encoding IL-4 gene of
RT Indian buffalo (Bubalus bubalis).";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; AY293620; AAP44996.1; -; mRNA.
DR AlphaFoldDB; Q7YS71; -.
DR SMR; Q7YS71; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..135
FT /note="Interleukin-4"
FT /id="PRO_0000015525"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..135
FT /evidence="ECO:0000250"
FT DISULFID 48..85
FT /evidence="ECO:0000250"
FT DISULFID 70..105
FT /evidence="ECO:0000250"
SQ SEQUENCE 135 AA; 15159 MW; FA52AE9FBE9F5070 CRC64;
MGLTYQLIPV LVCLLVCTSH LVHGHKCDIT LAEIIKTLNI LTTRKNSCME LPVADVFAAP
KNTTEKETFC RVGIELRRIY RSHTCLNKFL GGLDRNLNSL VSKTCSVNEA KTGTSTLKDL
LERLKTIMKE KYSKC