IL4_CANLF
ID IL4_CANLF Reviewed; 132 AA.
AC O77762; A1E293;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Beagle;
RX PubMed=9887351; DOI=10.1007/s002510050473;
RA van der Kaaij S.Y., Pinelli E., Broeren C.P.M., Schetters T.P.M.,
RA Haghparast A., Ruitenberg E.J., Rutten V.P.M.G.;
RT "Molecular cloning and sequencing of the cDNA for dog interleukin-4.";
RL Immunogenetics 49:142-143(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Beagle;
RA Boroughs K.L., Dreitz M., Sim G.-K.;
RT "Cloning and expression of canine IL4.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kobayashi H., Yoshida M., Nakagaki K., Katae H., Nogami S., Harasawa R.,
RA Maeda R., Hayashi Y., Yamamoto H.;
RT "Nucleotide sequence and deduced amino acid sequence of canine interleukin
RT 4 cDNA.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Beagle;
RX PubMed=10487243; DOI=10.1292/jvms.61.967;
RA Khatlani T.S., Ohno K., Ma Z., Inokuma H., Onishi T.;
RT "Cloning of a full length cDNA encoding canine interleukin-4.";
RL J. Vet. Med. Sci. 61:967-969(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11741347; DOI=10.1006/cyto.2001.0953;
RA Wondimu A., Veit M., Kohn B., Kaul S., Hoffmann A., Brunnberg L.,
RA Schmidt M.F.;
RT "Molecular cloning, expression and characterization of the Canis familiaris
RT interleukin-4.";
RL Cytokine 16:88-92(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Salunkhe S.S., Rai A., Saxena A., Tiwari A.K., Gupta P.K.;
RT "Amplification and cloning of canine interleukin-4 in mammalian expression
RT vector.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; AF054833; AAD11563.1; -; mRNA.
DR EMBL; AF083270; AAD09005.1; -; mRNA.
DR EMBL; AF104245; AAC83931.1; -; mRNA.
DR EMBL; AF187322; AAF01043.1; -; mRNA.
DR EMBL; AF239917; AAF60177.1; -; mRNA.
DR EMBL; EF095771; ABL01502.1; -; mRNA.
DR RefSeq; NP_001003159.1; NM_001003159.1.
DR AlphaFoldDB; O77762; -.
DR SMR; O77762; -.
DR STRING; 9615.ENSCAFP00000001253; -.
DR PaxDb; O77762; -.
DR Ensembl; ENSCAFT00030021538; ENSCAFP00030018780; ENSCAFG00030011649.
DR Ensembl; ENSCAFT00040011833; ENSCAFP00040010259; ENSCAFG00040006346.
DR Ensembl; ENSCAFT00845019424; ENSCAFP00845015186; ENSCAFG00845010991.
DR GeneID; 403785; -.
DR KEGG; cfa:403785; -.
DR CTD; 3565; -.
DR VEuPathDB; HostDB:ENSCAFG00845010991; -.
DR GeneTree; ENSGT00390000013108; -.
DR HOGENOM; CLU_154691_0_0_1; -.
DR InParanoid; O77762; -.
DR OMA; SCMELTV; -.
DR OrthoDB; 1495672at2759; -.
DR Reactome; R-CFA-6785807; Interleukin-4 and Interleukin-13 signaling.
DR Proteomes; UP000002254; Chromosome 11.
DR Bgee; ENSCAFG00000000880; Expressed in heart right ventricle and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IBA:GO_Central.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IBA:GO_Central.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IBA:GO_Central.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IBA:GO_Central.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IBA:GO_Central.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IBA:GO_Central.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
DR GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..132
FT /note="Interleukin-4"
FT /id="PRO_0000015526"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..84
FT /evidence="ECO:0000250"
FT DISULFID 70..104
FT /evidence="ECO:0000250"
SQ SEQUENCE 132 AA; 15267 MW; 6F75D8FBB6818945 CRC64;
MGLTSQLIPT LVCLLALTST FVHGHNFNIT IKEIIKMLNI LTARNDSCME LTVKDVFTAP
KNTSDKEIFC RAATVLRQIY THNCSNRYLR GLYRNLSSMA NKTCSMNEIK KSTLKDFLER
LKVIMQKKYY RH
