IL4_FELCA
ID IL4_FELCA Reviewed; 133 AA.
AC P55030; O62774; P79170;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Peripheral blood;
RA Schijns V.E.C.J., Wierda C.M.H., van Dam E.J.M., Vahlenkamp T.W.,
RA Horzinek M.C.;
RT "Molecular cloning of feline interleukin-4.";
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lerner D.L., Elder J.H.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-126.
RX PubMed=10391845; DOI=10.1128/cdli.6.4.471-478.1999;
RA Harley R., Helps C.R., Harbour D.A., Gruffydd-Jones T.J., Day M.J.;
RT "Cytokine mRNA expression in lesions in cats with chronic
RT gingivostomatitis.";
RL Clin. Diagn. Lab. Immunol. 6:471-478(1999).
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; X87408; CAA60856.1; -; Genomic_DNA.
DR EMBL; U39634; AAB42052.1; -; mRNA.
DR EMBL; AF054602; AAC15975.1; -; mRNA.
DR RefSeq; NP_001036804.1; NM_001043339.1.
DR AlphaFoldDB; P55030; -.
DR SMR; P55030; -.
DR STRING; 9685.ENSFCAP00000002290; -.
DR GeneID; 751514; -.
DR KEGG; fca:751514; -.
DR CTD; 3565; -.
DR eggNOG; KOG3886; Eukaryota.
DR HOGENOM; CLU_154691_0_0_1; -.
DR InParanoid; P55030; -.
DR OrthoDB; 1495672at2759; -.
DR TreeFam; TF336383; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IBA:GO_Central.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IBA:GO_Central.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IBA:GO_Central.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IBA:GO_Central.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IBA:GO_Central.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IBA:GO_Central.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..133
FT /note="Interleukin-4"
FT /id="PRO_0000015530"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 84
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..85
FT /evidence="ECO:0000250"
FT DISULFID 70..113
FT /evidence="ECO:0000250"
FT CONFLICT 2
FT /note="G -> D (in Ref. 2; AAB42052)"
FT /evidence="ECO:0000305"
FT CONFLICT 5
FT /note="Y -> S (in Ref. 2; AAB42052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 133 AA; 15148 MW; 6D94C71F61EFFC75 CRC64;
MGLTYQLIPA LVCLLAFTST FVHGQNFNNT LKEIIKTLNI LTARNDSCME LTVMDVLAAP
KNTSDKEIFC RATTVLRQIY THHNCSTKFL KGLDRNLSSM ANRTCSVNEV KKCTLKDFLE
RLKAIMQKKY SKH
