IL4_HORSE
ID IL4_HORSE Reviewed; 134 AA.
AC P42202; O46393; Q9GL85;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8042287; DOI=10.1016/0165-2427(94)90047-7;
RA Vandergrifft E.V., Swiderski C.E., Horohov D.W.;
RT "Molecular cloning and sequencing of equine interleukin 4.";
RL Vet. Immunol. Immunopathol. 40:379-384(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schrenzel M.D., Stannard A.A., Daft B., Ferrick D.A.;
RT "Horse (Equus caballus) interleukin-4 gene.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Steinbach F., Mauel S.;
RT "Cloning of equine interleukin 4 (IL-4).";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; L06010; AAA21299.1; -; mRNA.
DR EMBL; AF035404; AAB87701.1; -; mRNA.
DR EMBL; AF305617; AAG21896.1; -; mRNA.
DR RefSeq; NP_001075988.1; NM_001082519.1.
DR AlphaFoldDB; P42202; -.
DR SMR; P42202; -.
DR STRING; 9796.ENSECAP00000006431; -.
DR GeneID; 100034225; -.
DR KEGG; ecb:100034225; -.
DR CTD; 3565; -.
DR InParanoid; P42202; -.
DR OrthoDB; 1495672at2759; -.
DR Proteomes; UP000002281; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IBA:GO_Central.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IBA:GO_Central.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IBA:GO_Central.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IBA:GO_Central.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IBA:GO_Central.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IBA:GO_Central.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IBA:GO_Central.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..134
FT /note="Interleukin-4"
FT /id="PRO_0000015531"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 24..133
FT /evidence="ECO:0000250"
FT DISULFID 48..88
FT /evidence="ECO:0000250"
FT CONFLICT 5
FT /note="Y -> S (in Ref. 1; AAA21299)"
FT /evidence="ECO:0000305"
FT CONFLICT 8
FT /note="L -> I (in Ref. 3; AAG21896)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="S -> SN (in Ref. 3; AAG21896)"
FT /evidence="ECO:0000305"
FT CONFLICT 25
FT /note="K -> I (in Ref. 2; AAB87701)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="K -> I (in Ref. 2; AAB87701)"
FT /evidence="ECO:0000305"
FT CONFLICT 38
FT /note="N -> NN (in Ref. 3; AAG21896)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="G -> AG (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="Q -> QL (in Ref. 3; AAG21896)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="Missing (in Ref. 1; AAA21299)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="Missing (in Ref. 1; AAA21299)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="K -> R (in Ref. 1; AAA21299)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 14921 MW; CD609F0083B90F32 CRC64;
MGLTYQLLPA LVCLLACTSF IQGCKYDITL QEIIKTLNLT DGKGKNSCME LTVADAFGPK
NTDGKEICRA AKVLQQYKRH DRSLIKECLS GLDRNLKGMA NGTCCTVNEA KKSTLKDFLE
RLKTIMKEKY SKCS
