IL4_MACFA
ID IL4_MACFA Reviewed; 153 AA.
AC P79339; Q6YL20;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Tatsumi M.;
RT "Molecular cloning and expression of cynomolgus monkey IL-4.";
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=12466896; DOI=10.1007/s00251-002-0510-4;
RA Gautherot I., Burdin N., Seguin D., Aujame L., Sodoyer R.;
RT "Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee
RT and cynomolgus macaque: phylogenetic analysis of delta2 splice variant
RT appearance, and implications for the study of IL-4-driven immune
RT processes.";
RL Immunogenetics 54:635-644(2002).
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Long;
CC IsoId=P79339-1; Sequence=Displayed;
CC Name=2; Synonyms=Short, IL-4delta2;
CC IsoId=P79339-2; Sequence=VSP_013353;
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB000515; BAA19133.1; -; mRNA.
DR EMBL; AY130262; AAN06596.1; -; mRNA.
DR AlphaFoldDB; P79339; -.
DR BMRB; P79339; -.
DR SMR; P79339; -.
DR PRIDE; P79339; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
DR GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; B-cell activation; Cytokine; Disulfide bond;
KW Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..153
FT /note="Interleukin-4"
FT /id="PRO_0000015534"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..151
FT /evidence="ECO:0000255"
FT DISULFID 48..89
FT /evidence="ECO:0000255"
FT DISULFID 70..123
FT /evidence="ECO:0000255"
FT VAR_SEQ 46..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12466896"
FT /id="VSP_013353"
FT CONFLICT 22
FT /note="V -> A (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
FT CONFLICT 26..32
FT /note="KCDITLQ -> NCHIALR (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="K -> E (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="N -> S (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="N -> D (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="R -> K (in Ref. 1; BAA19133)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17471 MW; 4B740D4F9B6810A7 CRC64;
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTK LTITDILAAS
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL
NSCPVKEANQ STLENFLERL KTIMREKYSK CSS
