ID   IL4_MESAU               Reviewed;         147 AA.
AC   Q60440; O70330;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Interleukin-4;
DE            Short=IL-4;
DE   AltName: Full=B-cell stimulatory factor 1;
DE            Short=BSF-1;
DE   AltName: Full=Lymphocyte stimulatory factor 1;
DE   Flags: Precursor;
GN   Name=IL4;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Syrian;
RA   Wong D.T.W., Tsuji T.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-122.
RC   STRAIN=Syrian; TISSUE=Spleen;
RX   PubMed=9573100; DOI=10.1128/iai.66.5.2135-2142.1998;
RA   Melby P.C., Tryon V.V., Chandrasekar B., Freeman G.L.;
RT   "Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and
RT   analysis of cytokine mRNA expression in experimental visceral
RT   leishmaniasis.";
RL   Infect. Immun. 66:2135-2142(1998).
CC   -!- FUNCTION: Participates in at least several B-cell activation processes
CC       as well as of other cell types. It is a costimulator of DNA-synthesis.
CC       It induces the expression of class II MHC molecules on resting B-cells.
CC       It enhances both secretion and cell surface expression of IgE and IgG1.
CC       It also regulates the expression of the low affinity Fc receptor for
CC       IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC       IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC       cells by interfering with mTORC1 signaling and through the induction of
CC       RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR   EMBL; U50415; AAA96032.1; -; mRNA.
DR   EMBL; AF046213; AAC40098.1; -; mRNA.
DR   AlphaFoldDB; Q60440; -.
DR   SMR; Q60440; -.
DR   STRING; 10036.XP_005067826.1; -.
DR   eggNOG; KOG3886; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002354; IL-4.
DR   InterPro; IPR001325; IL-4/IL-13.
DR   InterPro; IPR018096; IL-4/IL-13_CS.
DR   PANTHER; PTHR47401; PTHR47401; 1.
DR   Pfam; PF00727; IL4; 1.
DR   PIRSF; PIRSF001941; Interleukin_4; 1.
DR   PRINTS; PR00431; INTERLEUKIN4.
DR   SMART; SM00190; IL4_13; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE   2: Evidence at transcript level;
KW   B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..147
FT                   /note="Interleukin-4"
FT                   /id="PRO_0000015537"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..87
FT                   /evidence="ECO:0000255"
FT   DISULFID        69..114
FT                   /evidence="ECO:0000255"
FT   CONFLICT        74..75
FT                   /note="GF -> VL (in Ref. 2; AAC40098)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   147 AA;  16732 MW;  47F687EE40D36C13 CRC64;
     MGLRPQLAAI LLCLLACTGN WTLGCHHGAL KEIIHILNQV TEKGTPCTEM VVPDALSARK
     NSTEKDLICR ASQGFRKFYF QHEVTLCLKN NSRVLKDLKK LYRGISSLFP QKSCNVNEST
     YTTLKDFLES LRRIMQKKYW QCGSSTF