IL4_PANTR
ID IL4_PANTR Reviewed; 153 AA.
AC Q8HYB1;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=12466896; DOI=10.1007/s00251-002-0510-4;
RA Gautherot I., Burdin N., Seguin D., Aujame L., Sodoyer R.;
RT "Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee
RT and cynomolgus macaque: phylogenetic analysis of delta2 splice variant
RT appearance, and implications for the study of IL-4-driven immune
RT processes.";
RL Immunogenetics 54:635-644(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sakagami T., Nakajima T., Saito N., Hayasaka I., Inoue I.;
RT "Pan troglodytes genomic region including interleukin 13 (IL13) gene and
RT interleukin 4 (IL4) gene.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Long;
CC IsoId=Q8HYB1-1; Sequence=Displayed;
CC Name=2; Synonyms=Short, IL-4delta2;
CC IsoId=Q8HYB1-2; Sequence=VSP_009090;
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; AY130260; AAN06594.1; -; mRNA.
DR EMBL; AY130261; AAN06595.1; -; mRNA.
DR EMBL; AY480012; AAR32990.1; -; Genomic_DNA.
DR RefSeq; NP_001008993.1; NM_001008993.1. [Q8HYB1-2]
DR RefSeq; NP_001011714.1; NM_001011714.1.
DR AlphaFoldDB; Q8HYB1; -.
DR BMRB; Q8HYB1; -.
DR SMR; Q8HYB1; -.
DR STRING; 9598.ENSPTRP00000029464; -.
DR PaxDb; Q8HYB1; -.
DR GeneID; 449565; -.
DR KEGG; ptr:449565; -.
DR CTD; 3565; -.
DR eggNOG; KOG3886; Eukaryota.
DR InParanoid; Q8HYB1; -.
DR OrthoDB; 1495672at2759; -.
DR TreeFam; TF336383; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; B-cell activation; Cytokine; Disulfide bond;
KW Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..153
FT /note="Interleukin-4"
FT /id="PRO_0000015539"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..151
FT /evidence="ECO:0000250"
FT DISULFID 48..89
FT /evidence="ECO:0000250"
FT DISULFID 70..123
FT /evidence="ECO:0000250"
FT VAR_SEQ 46..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12466896"
FT /id="VSP_009090"
FT CONFLICT 50
FT /note="E -> K (in Ref. 2; AAR32990)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="A -> T (in Ref. 1; AAN06594)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="N -> D (in Ref. 2; AAR32990)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17492 MW; 8725BF64B34D45F7 CRC64;
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL
NSCPVKEANQ STLENFLERL KTIMREKYSK CSS
