IL4_PIG
ID IL4_PIG Reviewed; 133 AA.
AC Q04745; Q29054; Q8MKE6;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8424960; DOI=10.1016/0167-4781(93)90077-q;
RA Bailey M., Perry A.C.F., Bland P.W., Stokes C.R., Hall L.;
RT "Nucleotide and deduced amino acid sequence of porcine interleukin 4 cDNA
RT derived from lamina propria lymphocytes.";
RL Biochim. Biophys. Acta 1171:328-330(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhou Y., Murtaugh M.P.;
RL Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Chenghua; TISSUE=Blood;
RA Liu S., Wu M., Gao R., Li J., Tang M., Long Z., Meng M.;
RT "Cloning and sequence analysis of interleukin-4 gene from Chenghua swine.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; X68330; CAA48407.1; -; mRNA.
DR EMBL; L12991; AAA31055.1; -; mRNA.
DR EMBL; AF493991; AAM27191.1; -; mRNA.
DR PIR; S28187; S28187.
DR RefSeq; NP_999288.1; NM_214123.1.
DR AlphaFoldDB; Q04745; -.
DR SMR; Q04745; -.
DR STRING; 9823.ENSSSCP00000015193; -.
DR PaxDb; Q04745; -.
DR Ensembl; ENSSSCT00000015605; ENSSSCP00000015193; ENSSSCG00000014282.
DR Ensembl; ENSSSCT00025077978; ENSSSCP00025033801; ENSSSCG00025056992.
DR Ensembl; ENSSSCT00035029644; ENSSSCP00035011462; ENSSSCG00035022691.
DR Ensembl; ENSSSCT00045024617; ENSSSCP00045017009; ENSSSCG00045014434.
DR Ensembl; ENSSSCT00065029701; ENSSSCP00065012139; ENSSSCG00065022324.
DR Ensembl; ENSSSCT00070039772; ENSSSCP00070033314; ENSSSCG00070020063.
DR GeneID; 397225; -.
DR KEGG; ssc:397225; -.
DR CTD; 3565; -.
DR VGNC; VGNC:89108; IL4.
DR eggNOG; KOG3886; Eukaryota.
DR GeneTree; ENSGT00390000013108; -.
DR HOGENOM; CLU_154691_0_0_1; -.
DR InParanoid; Q04745; -.
DR TreeFam; TF336383; -.
DR Reactome; R-SSC-6785807; Interleukin-4 and Interleukin-13 signaling.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Chromosome 2.
DR Bgee; ENSSSCG00000014282; Expressed in pituitary gland and 7 other tissues.
DR ExpressionAtlas; Q04745; baseline.
DR Genevisible; Q04745; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; IBA:GO_Central.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0001774; P:microglial cell activation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IBA:GO_Central.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IBA:GO_Central.
DR GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IBA:GO_Central.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IMP:AgBase.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IMP:AgBase.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IBA:GO_Central.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IBA:GO_Central.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IBA:GO_Central.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IBA:GO_Central.
DR GO; GO:1903142; P:positive regulation of establishment of endothelial barrier; IMP:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IBA:GO_Central.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IBA:GO_Central.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IBA:GO_Central.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IBA:GO_Central.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IBA:GO_Central.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IBA:GO_Central.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:AgBase.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IMP:AgBase.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IBA:GO_Central.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IBA:GO_Central.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR GO; GO:0046825; P:regulation of protein export from nucleus; IMP:AgBase.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..133
FT /note="Interleukin-4"
FT /id="PRO_0000015541"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..133
FT /evidence="ECO:0000250"
FT DISULFID 48..85
FT /evidence="ECO:0000250"
FT DISULFID 70..105
FT /evidence="ECO:0000250"
FT CONFLICT 45
FT /note="K -> E (in Ref. 3; AAM27191)"
FT /evidence="ECO:0000305"
FT CONFLICT 53..54
FT /note="VT -> GD (in Ref. 2; AAA31055)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="T -> R (in Ref. 2; AAA31055)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 133 AA; 15023 MW; 333033EF515D084F CRC64;
MGLTSQLIPT LVCLLACTSN FVHGHKCDIT LQEIIKTLNI LTARKNSCME LPVTDVFAAP
ENTTEKETFC RASTVLRHIY RHHTCMKSLL SGLDRNLSSM ANMTCSVHEA KKSTLKDFLE
RLKTIMKEKY SKC
