IL4_RABIT
ID IL4_RABIT Reviewed; 147 AA.
AC Q9MZR8; Q0MS70;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=10843729; DOI=10.1006/cyto.1999.0658;
RA Perkins H.D., van Leeuwen B.H., Hardy C.M., Kerr P.J.;
RT "The complete cDNA sequences of IL-2, IL-4, IL-6 and IL-10 from the
RT European rabbit (Oryctolagus cuniculus).";
RL Cytokine 12:555-565(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang D., Yang G., Gu X., Hao G., Wu K., Zhang X., Liu D., Jia X., Yang C.;
RT "Cloning and sequence analysis of IL-4 gene in rabbit.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; AF169169; AAF86653.1; -; mRNA.
DR EMBL; DQ852343; ABH10828.1; -; mRNA.
DR RefSeq; NP_001156649.1; NM_001163177.1.
DR AlphaFoldDB; Q9MZR8; -.
DR SMR; Q9MZR8; -.
DR STRING; 9986.ENSOCUP00000025135; -.
DR GeneID; 100302454; -.
DR KEGG; ocu:100302454; -.
DR CTD; 3565; -.
DR eggNOG; KOG3886; Eukaryota.
DR InParanoid; Q9MZR8; -.
DR OrthoDB; 1495672at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..147
FT /note="Interleukin-4"
FT /id="PRO_0000042272"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..88
FT /evidence="ECO:0000250"
SQ SEQUENCE 147 AA; 16562 MW; 1C3067FC04F827DD CRC64;
MGLPAQLPVT LLCLLAGTAH FIQGRRGDII LPEVIKTLNI LTERKTPCTK LMIADALAVP
KNTTEREAVC RAATALRQFY LHHKVSWCFK EHGELGDLRL LRGLDRNLCS MAKLSNCPGK
EARQTTLEDF LDRLKTAMQE KYSKRQS
