IL4_RAT
ID IL4_RAT Reviewed; 147 AA.
AC P20096;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell IGG differentiation factor;
DE AltName: Full=B-cell growth factor 1;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=Il4; Synonyms=Il-4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1903705; DOI=10.1002/eji.1830210514;
RA McKnight A.J., Barclay A.N., Mason D.W.;
RT "Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine
RT repertoire of subsets of CD4+ T cells.";
RL Eur. J. Immunol. 21:1187-1194(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1983334; DOI=10.1016/1043-4666(90)90020-t;
RA Richter G., Blankenstein T., Diamantstein T.;
RT "Evolutionary aspects, structure, and expression of the rat interleukin 4
RT gene.";
RL Cytokine 2:221-228(1990).
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; X16058; CAC16091.1; -; mRNA.
DR EMBL; X53087; CAA37256.2; -; Genomic_DNA.
DR EMBL; X53088; CAA37256.2; JOINED; Genomic_DNA.
DR EMBL; X53089; CAA37256.2; JOINED; Genomic_DNA.
DR PIR; A60237; ICRT4.
DR RefSeq; NP_958427.1; NM_201270.1.
DR AlphaFoldDB; P20096; -.
DR SMR; P20096; -.
DR STRING; 10116.ENSRNOP00000010029; -.
DR GlyGen; P20096; 3 sites.
DR PhosphoSitePlus; P20096; -.
DR PaxDb; P20096; -.
DR Ensembl; ENSRNOT00000010029; ENSRNOP00000010029; ENSRNOG00000007624.
DR GeneID; 287287; -.
DR KEGG; rno:287287; -.
DR UCSC; RGD:2898; rat.
DR CTD; 3565; -.
DR RGD; 2898; Il4.
DR eggNOG; KOG3886; Eukaryota.
DR GeneTree; ENSGT00390000013108; -.
DR InParanoid; P20096; -.
DR OMA; SCMELTV; -.
DR OrthoDB; 1495672at2759; -.
DR PhylomeDB; P20096; -.
DR TreeFam; TF336383; -.
DR Reactome; R-RNO-6785807; Interleukin-4 and Interleukin-13 signaling.
DR PRO; PR:P20096; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000007624; Expressed in ileum and 5 other tissues.
DR ExpressionAtlas; P20096; baseline and differential.
DR Genevisible; P20096; RN.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042976; P:activation of Janus kinase activity; ISO:RGD.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0031296; P:B cell costimulation; ISO:RGD.
DR GO; GO:0071288; P:cellular response to mercury ion; IEP:RGD.
DR GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
DR GO; GO:0042832; P:defense response to protozoan; ISO:RGD.
DR GO; GO:0097028; P:dendritic cell differentiation; ISO:RGD.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0002227; P:innate immune response in mucosa; ISO:RGD.
DR GO; GO:0042116; P:macrophage activation; ISO:RGD.
DR GO; GO:0001774; P:microglial cell activation; IDA:RGD.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; ISO:RGD.
DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IDA:RGD.
DR GO; GO:1903845; P:negative regulation of cellular response to transforming growth factor beta stimulus; ISO:RGD.
DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IDA:RGD.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; ISO:RGD.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:RGD.
DR GO; GO:0010633; P:negative regulation of epithelial cell migration; ISO:RGD.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0043031; P:negative regulation of macrophage activation; IMP:RGD.
DR GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:RGD.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:RGD.
DR GO; GO:0050868; P:negative regulation of T cell activation; ISO:RGD.
DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0070351; P:negative regulation of white fat cell proliferation; ISO:RGD.
DR GO; GO:0150076; P:neuroinflammatory response; IDA:ARUK-UCL.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISO:RGD.
DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IDA:ARUK-UCL.
DR GO; GO:2001171; P:positive regulation of ATP biosynthetic process; ISO:RGD.
DR GO; GO:0050871; P:positive regulation of B cell activation; ISO:RGD.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR GO; GO:1901857; P:positive regulation of cellular respiration; ISO:RGD.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IDA:RGD.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IDA:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:ARUK-UCL.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IDA:RGD.
DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:RGD.
DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISO:RGD.
DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISO:RGD.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; ISO:RGD.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISO:RGD.
DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IDA:RGD.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:RGD.
DR GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IDA:RGD.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:ARUK-UCL.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
DR GO; GO:0050776; P:regulation of immune response; ISO:RGD.
DR GO; GO:0050727; P:regulation of inflammatory response; IDA:RGD.
DR GO; GO:0010155; P:regulation of proton transport; IDA:RGD.
DR GO; GO:0034097; P:response to cytokine; IEP:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0060041; P:retina development in camera-type eye; IEP:RGD.
DR GO; GO:0042110; P:T cell activation; ISO:RGD.
DR GO; GO:0002296; P:T-helper 1 cell lineage commitment; ISO:RGD.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; ISO:RGD.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..147
FT /note="Interleukin-4"
FT /id="PRO_0000015542"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..87
FT /evidence="ECO:0000250"
SQ SEQUENCE 147 AA; 16247 MW; 1ED8658F6B6E1BC0 CRC64;
MGLSPHLAVT LFCFLICTGN GIHGCNDSPL REIINTLNQV TEKGTPCTEM FVPDVLTATR
NTTENELICR ASRVLRKFYF PRDVPPCLKN KSGVLGELRK LCRGVSGLNS LRSCTVNEST
LTTLKDFLES LKSILRGKYL QSCTSMS
