IL4_SHEEP
ID IL4_SHEEP Reviewed; 135 AA.
AC P30368; Q95MZ6;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Interleukin-4;
DE Short=IL-4;
DE AltName: Full=B-cell stimulatory factor 1;
DE Short=BSF-1;
DE AltName: Full=Lymphocyte stimulatory factor 1;
DE Flags: Precursor;
GN Name=IL4; Synonyms=IL-4;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8444353; DOI=10.1016/0378-1119(93)90408-u;
RA Seow H.F., Rothel J.S., Wood P.R.;
RT "Cloning and sequencing an ovine interleukin-4-encoding cDNA.";
RL Gene 124:291-293(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10805377; DOI=10.1089/107999000312360;
RA Chaplin P.J., Casey G., De Rose R., Buchan G., Wood P.R., Scheerlinck J.P.;
RT "The expression and biologic effects of ovine interleukin-4 on T and B cell
RT proliferation.";
RL J. Interferon Cytokine Res. 20:419-425(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 8-119.
RX PubMed=1457812; DOI=10.3109/10425179209034004;
RA Engwerda C.R., Sandeman M.;
RT "The isolation and sequence of sheep interleukin 4.";
RL DNA Seq. 3:111-113(1992).
CC -!- FUNCTION: Participates in at least several B-cell activation processes
CC as well as of other cell types. It is a costimulator of DNA-synthesis.
CC It induces the expression of class II MHC molecules on resting B-cells.
CC It enhances both secretion and cell surface expression of IgE and IgG1.
CC It also regulates the expression of the low affinity Fc receptor for
CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC cells by interfering with mTORC1 signaling and through the induction of
CC RUFY4. {ECO:0000250|UniProtKB:P07750}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; M96845; AAA31552.1; -; mRNA.
DR EMBL; AF172168; AAD49370.1; -; mRNA.
DR EMBL; Z11897; CAA77950.1; -; mRNA.
DR PIR; JU0139; JU0139.
DR RefSeq; NP_001009313.2; NM_001009313.2.
DR AlphaFoldDB; P30368; -.
DR SMR; P30368; -.
DR STRING; 9940.ENSOARP00000015980; -.
DR GeneID; 101122781; -.
DR KEGG; oas:101122781; -.
DR CTD; 3565; -.
DR eggNOG; KOG3886; Eukaryota.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0016239; P:positive regulation of macroautophagy; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR002354; IL-4.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR PANTHER; PTHR47401; PTHR47401; 1.
DR Pfam; PF00727; IL4; 1.
DR PIRSF; PIRSF001941; Interleukin_4; 1.
DR PRINTS; PR00431; INTERLEUKIN4.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW B-cell activation; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..135
FT /note="Interleukin-4"
FT /id="PRO_0000015543"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..85
FT /evidence="ECO:0000250"
FT DISULFID 70..105
FT /evidence="ECO:0000250"
FT CONFLICT 38
FT /note="L -> P (in Ref. 1; AAA31552)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="R -> Q (in Ref. 1; AAA31552)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="V -> A (in Ref. 1; AAA31552)"
FT /evidence="ECO:0000305"
FT CONFLICT 72
FT /note="A -> T (in Ref. 1; AAA31552)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 15136 MW; DFA6086C522C55A4 CRC64;
MGLTSQLIPA LVCLLVCTSH FVHGHKCDIT LEEIIKTLNI LTSRKNSCME LPVADVFAAP
KNATEKETFC RAGIELRRIY RSHMCLNKFL GGLDRNLSSL ASKTCSVNEA KTSTSTLRDL
LERLKTIMRE KYSKC
