ID   IL5_CANLF               Reviewed;         134 AA.
AC   Q95J76;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Interleukin-5;
DE            Short=IL-5;
DE   AltName: Full=Eosinophil differentiation factor;
DE   AltName: Full=T-cell replacing factor;
DE            Short=TRF;
DE   Flags: Precursor;
GN   Name=IL5;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=11440633; DOI=10.1089/107999001750277835;
RA   Yang S., Sellins K.S., Weber E., McCall C.;
RT   "Canine interleukin-5: molecular characterization of the gene and
RT   expression of biologically active recombinant protein.";
RL   J. Interferon Cytokine Res. 21:361-367(2001).
CC   -!- FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes
CC       and NK cells that plays an important role in the survival,
CC       differentiation, and chemotaxis of eosinophils. Acts also on activated
CC       and resting B-cells to induce immunoglobulin production, growth, and
CC       differentiation (By similarity). Mechanistically, exerts its biological
CC       effects through a receptor composed of IL5RA subunit and the cytokine
CC       receptor common subunit beta/CSF2RB. Binding to the receptor leads to
CC       activation of various kinases including LYN, SYK and JAK2 and thereby
CC       propagates signals through the RAS-MAPK and JAK-STAT5 pathways
CC       respectively (By similarity). {ECO:0000250|UniProtKB:P04401,
CC       ECO:0000250|UniProtKB:P05113}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts
CC       with CSF2RB. {ECO:0000250|UniProtKB:P04401,
CC       ECO:0000250|UniProtKB:P05113}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04401}.
CC   -!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000305}.
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DR   EMBL; AF331920; AAL10716.1; -; Genomic_DNA.
DR   EMBL; AF331919; AAL10715.1; -; mRNA.
DR   RefSeq; NP_001006951.1; NM_001006950.1.
DR   AlphaFoldDB; Q95J76; -.
DR   SMR; Q95J76; -.
DR   STRING; 9612.ENSCAFP00000001224; -.
DR   PaxDb; Q95J76; -.
DR   Ensembl; ENSCAFT00030022203; ENSCAFP00030019368; ENSCAFG00030011982.
DR   Ensembl; ENSCAFT00040011369; ENSCAFP00040009848; ENSCAFG00040006091.
DR   Ensembl; ENSCAFT00845018628; ENSCAFP00845014535; ENSCAFG00845010566.
DR   GeneID; 403790; -.
DR   KEGG; cfa:403790; -.
DR   CTD; 3567; -.
DR   VEuPathDB; HostDB:ENSCAFG00845010566; -.
DR   eggNOG; ENOG502RWD8; Eukaryota.
DR   GeneTree; ENSGT00390000016991; -.
DR   HOGENOM; CLU_156269_0_0_1; -.
DR   InParanoid; Q95J76; -.
DR   OMA; RWRVKKF; -.
DR   OrthoDB; 1417554at2759; -.
DR   TreeFam; TF338422; -.
DR   Proteomes; UP000002254; Chromosome 11.
DR   Bgee; ENSCAFG00000000855; Expressed in testis and 47 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005137; F:interleukin-5 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000186; IL-5.
DR   Pfam; PF02025; IL5; 1.
DR   PRINTS; PR00432; INTERLEUKIN5.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..134
FT                   /note="Interleukin-5"
FT                   /id="PRO_0000015555"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        63
FT                   /note="Interchain (with C-105)"
FT                   /evidence="ECO:0000250"
FT   DISULFID        105
FT                   /note="Interchain (with C-63)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  15307 MW;  003C86D94D6FF4C6 CRC64;
     MRMLLNLSLL ALGAAYVSAF AVENPMNRLV AETLTLLSTH RTWLIGDGNL MIPTPENKNH
     QLCIKEVFQG IDTLKNQTAH GEAVDKLFQN LSLIKEHIER QKKRCAGERW RVTKFLDYLQ
     VFLGVINTEW TPES