IL5_RAT
ID IL5_RAT Reviewed; 132 AA.
AC Q08125;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Interleukin-5;
DE Short=IL-5;
DE AltName: Full=B-cell growth factor II;
DE Short=BCGF-II;
DE AltName: Full=Cytotoxic T-lymphocyte inducer;
DE AltName: Full=Eosinophil differentiation factor;
DE AltName: Full=T-cell replacing factor;
DE Short=TRF;
DE Flags: Precursor;
GN Name=Il5; Synonyms=Il-5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Lewis;
RX PubMed=1653053; DOI=10.1016/1043-4666(91)90012-3;
RA Ueberla K.T., Li W., Guin Z., Richter G., Raabe T., Diamantstein T.,
RA Blanckenstein T.;
RT "The rat interleukin-5 gene: characterization and expression by retroviral
RT gene transfer and polymerase chain reaction.";
RL Cytokine 3:72-81(1991).
RN [2]
RP FUNCTION.
RX PubMed=10446387; DOI=10.1016/s0167-4889(99)00090-7;
RA Ishihara K., Satoh I., Nittoh T., Kanaya T., Okazaki H., Suzuki T.,
RA Koyama T., Sakamoto T., Ide T., Ohuchi K.;
RT "Preparation of recombinant rat interleukin-5 by baculovirus expression
RT system and analysis of its biological activities.";
RL Biochim. Biophys. Acta 1451:48-58(1999).
CC -!- FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes
CC and NK cells that plays an important role in the survival,
CC differentiation, and chemotaxis of eosinophils (PubMed:10446387). Acts
CC also on activated and resting B-cells to induce immunoglobulin
CC production, growth, and differentiation (By similarity).
CC Mechanistically, exerts its biological effects through a receptor
CC composed of IL5RA subunit and the cytokine receptor common subunit
CC beta/CSF2RB. Binding to the receptor leads to activation of various
CC kinases including LYN, SYK and JAK2 and thereby propagates signals
CC through the RAS-MAPK and JAK-STAT5 pathways respectively (By
CC similarity). {ECO:0000250|UniProtKB:P04401,
CC ECO:0000250|UniProtKB:P05113, ECO:0000269|PubMed:10446387}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with IL5RA. Interacts
CC with CSF2RB. {ECO:0000250|UniProtKB:P05113}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X54419; CAA38283.1; -; Genomic_DNA.
DR PIR; A48418; A48418.
DR AlphaFoldDB; Q08125; -.
DR SMR; Q08125; -.
DR STRING; 10116.ENSRNOP00000010729; -.
DR GlyGen; Q08125; 3 sites.
DR PaxDb; Q08125; -.
DR Ensembl; ENSRNOT00000010729; ENSRNOP00000010729; ENSRNOG00000008111.
DR UCSC; RGD:2900; rat.
DR RGD; 2900; Il5.
DR eggNOG; ENOG502RWD8; Eukaryota.
DR GeneTree; ENSGT00390000016991; -.
DR HOGENOM; CLU_156269_0_0_1; -.
DR InParanoid; Q08125; -.
DR OMA; RWRVKKF; -.
DR PhylomeDB; Q08125; -.
DR TreeFam; TF338422; -.
DR PRO; PR:Q08125; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000008111; Expressed in quadriceps femoris.
DR Genevisible; Q08125; RN.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0005125; F:cytokine activity; IDA:RGD.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005137; F:interleukin-5 receptor binding; IDA:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:RGD.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0045645; P:positive regulation of eosinophil differentiation; IDA:RGD.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0071803; P:positive regulation of podosome assembly; ISO:RGD.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IMP:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000186; IL-5.
DR Pfam; PF02025; IL5; 1.
DR PRINTS; PR00432; INTERLEUKIN5.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 3: Inferred from homology;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT CHAIN 20..132
FT /note="Interleukin-5"
FT /id="PRO_0000015565"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 61
FT /note="Interchain (with C-103)"
FT /evidence="ECO:0000250"
FT DISULFID 103
FT /note="Interchain (with C-61)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 132 AA; 15207 MW; 214A928B4C047031 CRC64;
MRMLLCLNVL TLSCVWAIAM EIPMSTVVKE TLIQLSTHRA LLTSNETMRL PVPTHKNHQL
CIGEIFQGLD ILKNQTVRGG TVEILFQNLS LIKKYIDGQK EKCGEERRKT RHFLDYLQEF
LGVMSTEWAM EV
