ID   IL6_ONCMY               Reviewed;         219 AA.
AC   Q0GGL7;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Interleukin-6;
DE            Short=IL-6;
DE   Flags: Precursor;
GN   Name=il6;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=17045654; DOI=10.1016/j.molimm.2006.07.297;
RA   Iliev D.B., Castellana B., Mackenzie S., Planas J.V., Goetz F.W.;
RT   "Cloning and expression analysis of an IL-6 homolog in rainbow trout
RT   (Oncorhynchus mykiss).";
RL   Mol. Immunol. 44:1803-1807(2007).
CC   -!- FUNCTION: Cytokine with a wide variety of biological functions in
CC       immunity, tissue regeneration, and metabolism. Binds to IL6R, then the
CC       complex associates to the signaling subunit IL6ST/gp130 to trigger the
CC       intracellular IL6-signaling pathway. The interaction with the membrane-
CC       bound IL6R and IL6ST stimulates 'classic signaling', whereas the
CC       binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.
CC       Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R
CC       complexes on transmitter cells activate IL6ST receptors on neighboring
CC       receiver cells. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBUNIT: Component of a hexamer of two molecules each of IL6, IL6R and
CC       IL6ST; first binds to IL6R to associate with the signaling subunit
CC       IL6ST. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05231}.
CC   -!- TISSUE SPECIFICITY: Expressed in spleen, gill and gastrointestinal
CC       tract, ovary and brain. Highest expression in ovary.
CC       {ECO:0000269|PubMed:17045654}.
CC   -!- INDUCTION: by LPS. {ECO:0000269|PubMed:17045654}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ866150; ABI48359.1; -; mRNA.
DR   RefSeq; NP_001118129.1; NM_001124657.1.
DR   AlphaFoldDB; Q0GGL7; -.
DR   SMR; Q0GGL7; -.
DR   GeneID; 100136689; -.
DR   KEGG; omy:100136689; -.
DR   CTD; 3569; -.
DR   OrthoDB; 1144279at2759; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR   GO; GO:0042976; P:activation of Janus kinase activity; IMP:AgBase.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IDA:AgBase.
DR   GO; GO:0071354; P:cellular response to interleukin-6; IDA:AgBase.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:AgBase.
DR   GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR   GO; GO:0072574; P:hepatocyte proliferation; ISS:UniProtKB.
DR   GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IDA:AgBase.
DR   GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0097421; P:liver regeneration; ISS:UniProtKB.
DR   GO; GO:0061517; P:macrophage proliferation; IDA:AgBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR   GO; GO:0045089; P:positive regulation of innate immune response; IMP:AgBase.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IDA:AgBase.
DR   GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISS:UniProtKB.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:AgBase.
DR   GO; GO:0070092; P:regulation of glucagon secretion; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0014823; P:response to activity; ISS:UniProtKB.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR   GO; GO:0010573; P:vascular endothelial growth factor production; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   PANTHER; PTHR10511:SF3; PTHR10511:SF3; 1.
DR   Pfam; PF00489; IL6; 1.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Cytokine; Disulfide bond; Growth factor; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..219
FT                   /note="Interleukin-6"
FT                   /id="PRO_0000387949"
FT   DISULFID        103..111
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24497 MW;  27EAECB636D850BD CRC64;
     MNSSTRYLSL LSALVVLVKG NPVPSALAEL MTSGWTSGEE LGTDGETGAP PKWEKMIKML
     VHEVTTLRNQ QFVEEFQKPV EEISSFSQHQ VPSTPPHLSK TLCSASNKEA CLQEISRGLQ
     VYQLLLQHVK AEYPQSTLLP SVTHQTTVLI GLVKDQMKVA EVVEDLSASE RKRVLGEVST
     GTEWERKTSV HAILRELRNF LVDTKRALRR MGKRGKDFQ