ID   IL6_TAKRU               Reviewed;         227 AA.
AC   Q6L6X6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Interleukin-6;
DE            Short=IL-6;
DE   Flags: Precursor;
GN   Name=il6;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP   INDUCTION.
RX   PubMed=15936434; DOI=10.1016/j.dci.2005.01.002;
RA   Bird S., Zou J., Savan R., Kono T., Sakai M., Woo J., Secombes C.;
RT   "Characterisation and expression analysis of an interleukin 6 homologue in
RT   the Japanese pufferfish, Fugu rubripes.";
RL   Dev. Comp. Immunol. 29:775-789(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ram S., Sakai M.;
RT   "Characterization of a novel interleukin 6 from fugu.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine with a wide variety of biological functions in
CC       immunity, tissue regeneration, and metabolism. Binds to IL6R, then the
CC       complex associates to the signaling subunit IL6ST/gp130 to trigger the
CC       intracellular IL6-signaling pathway. The interaction with the membrane-
CC       bound IL6R and IL6ST stimulates 'classic signaling', whereas the
CC       binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'.
CC       Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R
CC       complexes on transmitter cells activate IL6ST receptors on neighboring
CC       receiver cells. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBUNIT: Component of a hexamer of two molecules each of IL6, IL6R and
CC       IL6ST; first binds to IL6R to associate with the signaling subunit
CC       IL6ST. {ECO:0000250|UniProtKB:P05231}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05231}.
CC   -!- TISSUE SPECIFICITY: After induction, highly expressed in spleen. Can
CC       also be expressed in kidney after incubation with PHA.
CC       {ECO:0000269|PubMed:15936434}.
CC   -!- INDUCTION: By LPS and PBS. {ECO:0000269|PubMed:15936434}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ544721; CAD67608.1; -; mRNA.
DR   EMBL; AJ544722; CAD67609.1; -; Genomic_DNA.
DR   EMBL; AB178902; BAD18930.1; -; Genomic_DNA.
DR   RefSeq; NP_001027894.1; NM_001032722.1.
DR   AlphaFoldDB; Q6L6X6; -.
DR   SMR; Q6L6X6; -.
DR   STRING; 31033.ENSTRUP00000021935; -.
DR   Ensembl; ENSTRUT00000022026; ENSTRUP00000021936; ENSTRUG00000008735.
DR   GeneID; 503562; -.
DR   KEGG; tru:503562; -.
DR   CTD; 100628202; -.
DR   GeneTree; ENSGT00390000000878; -.
DR   HOGENOM; CLU_1253220_0_0_1; -.
DR   InParanoid; Q6L6X6; -.
DR   OrthoDB; 1144279at2759; -.
DR   Proteomes; UP000005226; Chromosome 12.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR   GO; GO:0072574; P:hepatocyte proliferation; ISS:UniProtKB.
DR   GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0097421; P:liver regeneration; ISS:UniProtKB.
DR   GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISS:UniProtKB.
DR   GO; GO:0070092; P:regulation of glucagon secretion; ISS:UniProtKB.
DR   GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB.
DR   GO; GO:0014823; P:response to activity; ISS:UniProtKB.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR   GO; GO:0010573; P:vascular endothelial growth factor production; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   PANTHER; PTHR10511:SF3; PTHR10511:SF3; 1.
DR   Pfam; PF00489; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Acute phase; Cytokine; Disulfide bond; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..227
FT                   /note="Interleukin-6"
FT                   /id="PRO_0000387952"
FT   REGION          24..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        93..103
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   227 AA;  25606 MW;  E6ABE6215B397D3B CRC64;
     MASISYLLAP LVLAAVLQPT AGAPLDAPTE SPAGETSGEE AETGSPDDAL AVALESVLGA
     TKLHKNEFLV EFQGEVKYDF LDRYKIPSLP AKCPYSNFGK DACLRRLLEG LLIYSVLLKR
     VEEEFPSSSI LSEVRFYSNI LIKELENKVR DRDQVMRLTS SQEEQLLKDT DYPDTFHRKM
     TAHGILYNLH YFLVDCRRVI NKRAKHRESA GSRVVRAVTF YHPKKRS