IL7_BOVIN
ID IL7_BOVIN Reviewed; 176 AA.
AC P26895; A5PKF2; A9QWR0;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Interleukin-7;
DE Short=IL-7;
DE Flags: Precursor;
GN Name=IL7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Holstein;
RX PubMed=1333837; DOI=10.3109/10425179209039696;
RA Cludts I., Droogmans L., Cleuter Y., Kettmann R., Burny A.;
RT "Sequence of bovine interleukin 7.";
RL DNA Seq. 3:55-59(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Belted Galloway; TISSUE=Peripheral blood;
RG U.S. Veterinary Immune Reagent Network;
RA Hudgens T., Tompkins D., Baldwin C.L.;
RT "U.S. veterinary immune reagent network: expressed bovine gene sequences.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC development, expansion, and survival of naive and memory T-cells and B-
CC cells thereby regulating the number of mature lymphocytes and
CC maintaining lymphoid homeostasis. Mechanistically, exerts its
CC biological effects through a receptor composed of IL7RA subunit and the
CC cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor
CC leads to activation of various kinases including JAK1 or JAK3 depending
CC on the cell type and subsequently propagation of signals through
CC activation of several downstream signaling pathways including the
CC PI3K/Akt/mTOR or the JAK-STAT5. {ECO:0000250|UniProtKB:P13232}.
CC -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC {ECO:0000250|UniProtKB:P13232}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13232}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
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DR EMBL; X64540; CAA45838.1; -; Genomic_DNA.
DR EMBL; EU276072; ABX72070.1; -; mRNA.
DR EMBL; BC142466; AAI42467.1; -; mRNA.
DR PIR; A56652; A56652.
DR AlphaFoldDB; P26895; -.
DR SMR; P26895; -.
DR STRING; 9913.ENSBTAP00000021659; -.
DR PaxDb; P26895; -.
DR Ensembl; ENSBTAT00000021659; ENSBTAP00000021659; ENSBTAG00000016284.
DR VEuPathDB; HostDB:ENSBTAG00000016284; -.
DR VGNC; VGNC:30169; IL7.
DR eggNOG; ENOG502SW6R; Eukaryota.
DR GeneTree; ENSGT00390000004451; -.
DR HOGENOM; CLU_129929_1_0_1; -.
DR InParanoid; P26895; -.
DR OMA; VFFCNDT; -.
DR TreeFam; TF338065; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000016284; Expressed in corpus epididymis and 85 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0045453; P:bone resorption; ISS:UniProtKB.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043086; P:negative regulation of catalytic activity; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; ISS:UniProtKB.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0002360; P:T cell lineage commitment; IEA:Ensembl.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR018049; IL-7/IL-9_CS.
DR InterPro; IPR038325; IL7_sf.
DR Pfam; PF01415; IL7; 1.
DR PIRSF; PIRSF001942; IL-7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
DR PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..176
FT /note="Interleukin-7"
FT /id="PRO_0000015622"
FT REGION 118..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..165
FT /evidence="ECO:0000250"
FT DISULFID 58..153
FT /evidence="ECO:0000250"
FT DISULFID 71..116
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 20023 MW; C79398B512DBEC8F CRC64;
MFHVSFRYIF GIPPLILVLL PVASSDCDIS GKDGGAYQNV LMVNIDDLDN MINFDSNCLN
NEPNFFKKHS CDDNKEASFL NRASRKLRQF LKMNISDDFK LHLSTVSQGT LTLLNCTSKG
KGRKPPSLSE AQPTKNLEEN KSSKEQKKQN DLCFLKILLQ KIKTCWNKIL RGIKEH
