IL7_MOUSE
ID IL7_MOUSE Reviewed; 154 AA.
AC P10168;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Interleukin-7;
DE Short=IL-7;
DE Flags: Precursor;
GN Name=Il7; Synonyms=Il-7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=3259677; DOI=10.1038/333571a0;
RA Namen A.E., Lupton S., Hjerrild K., Wignall J., Mochizuki D.Y.,
RA Schmierer A., Mosley B., March C.J., Urdal D., Gillis S., Cosman D.,
RA Goodwin R.G.;
RT "Stimulation of B-cell progenitors by cloned murine interleukin-7.";
RL Nature 333:571-573(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-119.
RX PubMed=2329282;
RA Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D.,
RA Goodwin R.G.;
RT "Characterization of the human and murine IL-7 genes.";
RL J. Immunol. 144:3592-3601(1990).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=7699333; DOI=10.1084/jem.181.4.1519;
RA von Freeden-Jeffry U., Vieira P., Lucian L.A., McNeil T., Burdach S.E.,
RA Murray R.;
RT "Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a
RT nonredundant cytokine.";
RL J. Exp. Med. 181:1519-1526(1995).
RN [4]
RP FUNCTION.
RX PubMed=28811625; DOI=10.1038/icb.2017.68;
RA Plumb A.W., Sheikh A., Carlow D.A., Patton D.T., Ziltener H.J., Abraham N.;
RT "Interleukin-7 in the transition of bone marrow progenitors to the
RT thymus.";
RL Immunol. Cell Biol. 95:916-924(2017).
CC -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC development, expansion, and survival of naive and memory T-cells and B-
CC cells thereby regulating the number of mature lymphocytes and
CC maintaining lymphoid homeostasis (PubMed:7699333, PubMed:28811625).
CC Mechanistically, exerts its biological effects through a receptor
CC composed of IL7RA subunit and the cytokine receptor common subunit
CC gamma/CSF2RG. Binding to the receptor leads to activation of various
CC kinases including JAK1 or JAK3 depending on the cell type and
CC subsequently propagation of signals through activation of several
CC downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-
CC STAT5. {ECO:0000250|UniProtKB:P13232, ECO:0000269|PubMed:28811625,
CC ECO:0000269|PubMed:7699333}.
CC -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC {ECO:0000250|UniProtKB:P13232}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13232}.
CC -!- PTM: Three disulfide bonds are present. {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Deletion mice appear healthy at birth and develop
CC normally. Both sexes are fertile. However, they exhibit severe
CC peripheral blood and tissue lymphoid abnormalities showing a strong
CC dependence on IL7 for proper expansion of lymphoid lineages.
CC {ECO:0000269|PubMed:7699333}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
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DR EMBL; X07962; CAA30779.1; -; mRNA.
DR EMBL; M29057; AAA39303.1; -; Genomic_DNA.
DR EMBL; M29054; AAA39303.1; JOINED; Genomic_DNA.
DR EMBL; M29055; AAA39303.1; JOINED; Genomic_DNA.
DR EMBL; M29056; AAA39303.1; JOINED; Genomic_DNA.
DR CCDS; CCDS50859.1; -.
DR PIR; S03171; S03171.
DR RefSeq; NP_032397.1; NM_008371.5.
DR AlphaFoldDB; P10168; -.
DR SMR; P10168; -.
DR STRING; 10090.ENSMUSP00000126219; -.
DR GlyGen; P10168; 2 sites.
DR PaxDb; P10168; -.
DR PRIDE; P10168; -.
DR ProteomicsDB; 267236; -.
DR Antibodypedia; 12401; 780 antibodies from 37 providers.
DR DNASU; 16196; -.
DR Ensembl; ENSMUST00000194279; ENSMUSP00000141845; ENSMUSG00000040329.
DR GeneID; 16196; -.
DR KEGG; mmu:16196; -.
DR UCSC; uc008ooi.1; mouse.
DR CTD; 3574; -.
DR MGI; MGI:96561; Il7.
DR VEuPathDB; HostDB:ENSMUSG00000040329; -.
DR eggNOG; ENOG502SW6R; Eukaryota.
DR GeneTree; ENSGT00390000004451; -.
DR HOGENOM; CLU_129929_1_0_1; -.
DR InParanoid; P10168; -.
DR OMA; VFFCNDT; -.
DR OrthoDB; 1433958at2759; -.
DR PhylomeDB; P10168; -.
DR TreeFam; TF338065; -.
DR BioGRID-ORCS; 16196; 3 hits in 73 CRISPR screens.
DR PRO; PR:P10168; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P10168; protein.
DR Bgee; ENSMUSG00000040329; Expressed in secondary oocyte and 71 other tissues.
DR ExpressionAtlas; P10168; baseline and differential.
DR Genevisible; P10168; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0008083; F:growth factor activity; IDA:MGI.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0042100; P:B cell proliferation; IGI:MGI.
DR GO; GO:0045453; P:bone resorption; IDA:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:MGI.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043086; P:negative regulation of catalytic activity; IDA:MGI.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IDA:MGI.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
DR GO; GO:0035265; P:organ growth; IMP:MGI.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IDA:MGI.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IDA:MGI.
DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI.
DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR GO; GO:0046622; P:positive regulation of organ growth; IMP:MGI.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
DR GO; GO:0002360; P:T cell lineage commitment; IMP:MGI.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR018049; IL-7/IL-9_CS.
DR InterPro; IPR038325; IL7_sf.
DR Pfam; PF01415; IL7; 1.
DR PIRSF; PIRSF001942; IL-7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
DR PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE 1: Evidence at protein level;
KW Cytokine; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT CHAIN 26..154
FT /note="Interleukin-7"
FT /id="PRO_0000015624"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..145
FT /evidence="ECO:0000250|UniProtKB:P13232"
FT DISULFID 58..133
FT /evidence="ECO:0000250|UniProtKB:P13232"
FT DISULFID 71..116
FT /evidence="ECO:0000250|UniProtKB:P13232"
SQ SEQUENCE 154 AA; 17727 MW; CBAAB7A1A7516A42 CRC64;
MFHVSFRYIF GIPPLILVLL PVTSSECHIK DKEGKAYESV LMISIDELDK MTGTDSNCPN
NEPNFFRKHV CDDTKEAAFL NRAARKLKQF LKMNISEEFN VHLLTVSQGT QTLVNCTSKE
EKNVKEQKKN DACFLKRLLR EIKTCWNKIL KGSI
