IL7_PIG
ID IL7_PIG Reviewed; 176 AA.
AC Q9N2G6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Interleukin-7;
DE Short=IL-7;
DE Flags: Precursor;
GN Name=IL7;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Intestine;
RX PubMed=11342229; DOI=10.1016/s0167-4781(00)00304-3;
RA Ueha S., Kitazawa H., Tomioka Y., Kawai Y., Saito T., Itoh T.;
RT "cDNA cloning and expression of swine IL-7 from neonatal intestinal
RT epithelium.";
RL Biochim. Biophys. Acta 1517:468-471(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Spleen;
RX PubMed=11474182; DOI=10.1159/000056951;
RA Uenishi H., Hiraiwa H., Sawazaki T., Kiuchi S., Yasue H.;
RT "Genomic organization and assignment of the interleukin 7 gene (IL7) to
RT porcine chromosome 4q11-->q13 by FISH and by analysis of radiation hybrid
RT panels.";
RL Cytogenet. Cell Genet. 93:65-72(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Peripheral blood;
RG U.S. Veterinary Immune Reagent Network;
RA Boyd P., Tompkins D., Hudgens T., Baldwin C.L., Lunney J.;
RT "U.S. veterinary immune reagent network: expressed swine gene sequences.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hematopoietic growth factor capable of stimulating the
CC proliferation of lymphoid progenitors. It is important for
CC proliferation during certain stages of B-cell maturation.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
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DR EMBL; AB035380; BAA96385.1; -; mRNA.
DR EMBL; AB040441; BAB39170.1; -; mRNA.
DR EMBL; AB049332; BAB39172.1; -; Genomic_DNA.
DR EMBL; EU364895; ABY66141.1; -; mRNA.
DR RefSeq; NP_999300.1; NM_214135.2.
DR AlphaFoldDB; Q9N2G6; -.
DR SMR; Q9N2G6; -.
DR STRING; 9823.ENSSSCP00000006572; -.
DR PaxDb; Q9N2G6; -.
DR Ensembl; ENSSSCT00005005479; ENSSSCP00005003149; ENSSSCG00005003411.
DR Ensembl; ENSSSCT00030065235; ENSSSCP00030029799; ENSSSCG00030046702.
DR Ensembl; ENSSSCT00060017140; ENSSSCP00060006811; ENSSSCG00060013039.
DR Ensembl; ENSSSCT00070034017; ENSSSCP00070028409; ENSSSCG00070017230.
DR GeneID; 397253; -.
DR KEGG; ssc:397253; -.
DR CTD; 3574; -.
DR eggNOG; ENOG502SW6R; Eukaryota.
DR HOGENOM; CLU_129929_1_0_1; -.
DR InParanoid; Q9N2G6; -.
DR OMA; VFFCNDT; -.
DR OrthoDB; 1433958at2759; -.
DR TreeFam; TF338065; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 4.
DR Genevisible; Q9N2G6; SS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR GO; GO:0045453; P:bone resorption; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0043086; P:negative regulation of catalytic activity; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0002360; P:T cell lineage commitment; IEA:Ensembl.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR038325; IL7_sf.
DR Pfam; PF01415; IL7; 1.
DR PIRSF; PIRSF001942; IL-7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
DR SMART; SM00127; IL7; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..176
FT /note="Interleukin-7"
FT /id="PRO_0000326172"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..165
FT /evidence="ECO:0000250"
FT DISULFID 58..153
FT /evidence="ECO:0000250"
FT DISULFID 71..116
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 20161 MW; 9FB75E272BDCBBEF CRC64;
MFHVSFRYIF GIPPLILVLL PVASSDCDIE GKDGGVYQNV LMVSIDDLDR MIDFDSNCLN
NEPNFLKKHS CDDNKEASFL YRAARKLKQF IKMNISEEFN HHLSTVSQGT LTLFNCTSKV
KGRKPPSLGE AQLTKNLEEN KSLKEQKRQG DLCFLKILLQ KIKTCWNKIL RGAKEY
