ID   IL7_RAT                 Reviewed;         154 AA.
AC   P56478;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Interleukin-7;
DE            Short=IL-7;
DE   Flags: Precursor;
GN   Name=Il7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fischer;
RA   Widegren B., Visse E., Sjogren H.O.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC       development, expansion, and survival of naive and memory T-cells and B-
CC       cells thereby regulating the number of mature lymphocytes and
CC       maintaining lymphoid homeostasis. Mechanistically, exerts its
CC       biological effects through a receptor composed of IL7RA subunit and the
CC       cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor
CC       leads to activation of various kinases including JAK1 or JAK3 depending
CC       on the cell type and subsequently propagation of signals through
CC       activation of several downstream signaling pathways including the
CC       PI3K/Akt/mTOR or the JAK-STAT5. {ECO:0000250|UniProtKB:P13232}.
CC   -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC       {ECO:0000250|UniProtKB:P13232}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13232}.
CC   -!- PTM: Three disulfide bonds are present. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
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DR   EMBL; AF010464; AAB66350.1; -; mRNA.
DR   AlphaFoldDB; P56478; -.
DR   SMR; P56478; -.
DR   STRING; 10116.ENSRNOP00000016091; -.
DR   GlyGen; P56478; 2 sites.
DR   PaxDb; P56478; -.
DR   PRIDE; P56478; -.
DR   UCSC; RGD:2904; rat.
DR   RGD; 2904; Il7.
DR   eggNOG; ENOG502SW6R; Eukaryota.
DR   InParanoid; P56478; -.
DR   PhylomeDB; P56478; -.
DR   PRO; PR:P56478; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR   GO; GO:0045453; P:bone resorption; ISS:UniProtKB.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0048873; P:homeostasis of number of cells within a tissue; ISO:RGD.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043086; P:negative regulation of catalytic activity; ISO:RGD.
DR   GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; ISO:RGD.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR   GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
DR   GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0046622; P:positive regulation of organ growth; ISO:RGD.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR   GO; GO:0010165; P:response to X-ray; IEP:RGD.
DR   GO; GO:0002360; P:T cell lineage commitment; ISO:RGD.
DR   Gene3D; 1.20.1250.50; -; 1.
DR   InterPro; IPR001181; IL-7.
DR   InterPro; IPR018049; IL-7/IL-9_CS.
DR   InterPro; IPR038325; IL7_sf.
DR   Pfam; PF01415; IL7; 1.
DR   PIRSF; PIRSF001942; IL-7; 1.
DR   PRINTS; PR00435; INTERLEUKIN7.
DR   SMART; SM00127; IL7; 1.
DR   PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..154
FT                   /note="Interleukin-7"
FT                   /id="PRO_0000015625"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..145
FT                   /evidence="ECO:0000250|UniProtKB:P13232"
FT   DISULFID        58..133
FT                   /evidence="ECO:0000250|UniProtKB:P13232"
FT   DISULFID        71..116
FT                   /evidence="ECO:0000250|UniProtKB:P13232"
SQ   SEQUENCE   154 AA;  17709 MW;  8D9E9E9FD0681741 CRC64;
     MFHVSFRYIF GIPPLILVLL PVTSSDCHIK DKDGKAFGSV LMISINQLDK MTGTDSDCPN
     NEPNFFKKHL CDDTKEAAFL NRAARKLRQF LKMNISEEFN DHLLRVSDGT QTLVNCTSKE
     EKTIKEQKKN DPCFLKRLLR EIKTCWNKIL KGSI