ID   IL7_SHEEP               Reviewed;         176 AA.
AC   Q28540;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Interleukin-7;
DE            Short=IL-7;
DE   Flags: Precursor;
GN   Name=IL7;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lymph node;
RX   PubMed=7890175; DOI=10.1016/0378-1119(94)00857-o;
RA   Barcham G.J., Andrews A.E., Nash A.D.;
RT   "Cloning and expression of a cDNA encoding ovine interleukin 7.";
RL   Gene 154:265-269(1995).
CC   -!- FUNCTION: Hematopoietic cytokine that plays an essential role in the
CC       development, expansion, and survival of naive and memory T-cells and B-
CC       cells thereby regulating the number of mature lymphocytes and
CC       maintaining lymphoid homeostasis. Mechanistically, exerts its
CC       biological effects through a receptor composed of IL7RA subunit and the
CC       cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor
CC       leads to activation of various kinases including JAK1 or JAK3 depending
CC       on the cell type and subsequently propagation of signals through
CC       activation of several downstream signaling pathways including the
CC       PI3K/Akt/mTOR or the JAK-STAT5. {ECO:0000250|UniProtKB:P13232}.
CC   -!- SUBUNIT: Interacts with IL7R and CSF2RG.
CC       {ECO:0000250|UniProtKB:P13232}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13232}.
CC   -!- SIMILARITY: Belongs to the IL-7/IL-9 family. {ECO:0000305}.
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DR   EMBL; U10089; AAA78269.1; -; mRNA.
DR   PIR; JC4035; JC4035.
DR   RefSeq; NP_001009777.1; NM_001009777.1.
DR   AlphaFoldDB; Q28540; -.
DR   SMR; Q28540; -.
DR   STRING; 9940.ENSOARP00000008461; -.
DR   Ensembl; ENSOART00020024714; ENSOARP00020020499; ENSOARG00020016028.
DR   GeneID; 443341; -.
DR   KEGG; oas:443341; -.
DR   CTD; 3574; -.
DR   eggNOG; ENOG502SW6R; Eukaryota.
DR   OrthoDB; 1433958at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR   GO; GO:0042100; P:B cell proliferation; IEA:Ensembl.
DR   GO; GO:0045453; P:bone resorption; ISS:UniProtKB.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0043086; P:negative regulation of catalytic activity; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR   GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:Ensembl.
DR   GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR   GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR   GO; GO:0045582; P:positive regulation of T cell differentiation; ISS:UniProtKB.
DR   GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0002360; P:T cell lineage commitment; IEA:Ensembl.
DR   Gene3D; 1.20.1250.50; -; 1.
DR   InterPro; IPR001181; IL-7.
DR   InterPro; IPR018049; IL-7/IL-9_CS.
DR   InterPro; IPR038325; IL7_sf.
DR   Pfam; PF01415; IL7; 1.
DR   PIRSF; PIRSF001942; IL-7; 1.
DR   PRINTS; PR00435; INTERLEUKIN7.
DR   SMART; SM00127; IL7; 1.
DR   PROSITE; PS00255; INTERLEUKIN_7_9; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..176
FT                   /note="Interleukin-7"
FT                   /id="PRO_0000015626"
FT   REGION          119..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        140
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..165
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..153
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..116
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   176 AA;  19983 MW;  87A448FD38142D17 CRC64;
     MFHVSFRYIF GIPPLILVLL PVASSDCDFS GKDGGAYQNV LMVSIDDLDN MINFDSNCLN
     NEPNFFKKHS CDDNKEASFL NRAARKLKQF LKMNISDDFK LHLSTVSQGT LTLLNCTSKG
     KGRKPPSLGE AQPTKNLEEN KSLKEQRKQN DLCFLKILLQ KIKTCWNKIL RGITEH